Interest of Eye Movement Measurements in the Comprehension of Dry Eyes Symptoms

Completed

• Conditions: Dry Eye Syndromes; Blinking
• Interventions: Device: Infrared oculography

• Registration Number: NCT02851654
• Lead Sponsor: Fondation Ophtalmologique Adolphe de Rothschild

Brief Summary

Dry eye syndrome is a benign situation however its impact on patient's quality of live and on health system is not trivial. One problem is the lack of correlation between patient's symptoms and physical sign observed on slit lamp examination. Eye blinking is a parameter of increased interest in this pathology particularly its frequency. To date no treatment of dry eye syndrome has a proven impact on eye blinking frequency. However recording of blinks has mostly been performed on short duration (3 to 5 minutes) and the distribution of intervals between 2 blinks is not gaussian but exponential. In this study, it is proposed to use modern eye-movement recorder to measure the blink frequency on longer duration (12 minutes) while reading on a screen computer and during a face-to-face interview before and after treatment of meibomian gland dysfunction responsible of moderate to severe dry eye syndrome.

Detailed Description

Not available

Study Timeline

• Study Start: 2014-11-05
• Study First Submitted: 2016-07-28
• Study First Submitted QC: 2016-07-28
• Study First Posted: 2016-08-01
• Primary Completion: 2019-10-30
• Study Completion: 2019-10-30
• Status Verified: 2019-12
• Last Update Submitted: 2019-12-10
• Last Update Posted: 2019-12-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 24

Inclusion Criteria

• Moderate to severe dry eye syndrome (Ocular Surface Disease Index> 30) following a meibomian gland dysfunction
• Not yet properly treated for a meibomian gland dysfunction

Exclusion Criteria

• History of other ophthalmological or neurological disease
• Pregnant or breastfeeding women
• Patient under 18 years old
• Patient under legal protection

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Dry eye syndrome	Infrared oculography	Meibomian gland dysfunction responsible of moderate to severe dry eye syndrome

Primary Outcome Measures

Name	Time	Method
duration between 2 blinks	2 months after treatment	Assessment by infrared oculography while the patient is reading on a computer screen and during a face-to-face interview

Trial Locations

Locations (1)

Fondation Ophtalmologique Adolphe de Rothschild (FOR); 🇫🇷 Paris, France