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Clinical Trials/CTRI/2012/12/003251
CTRI/2012/12/003251Not yet recruiting未知

Effect of prophylactic isosorbide mononitrate on the incidence of preeclampsia in high risk women â?? A double blind randomized controlled trial. - NOPE (Nitric Oxide in Prevention of pre-Eclampsia) Trial

Jawaharlal Institute of Post graduate Medical Education and Research0 sites100 target enrollmentStarted: TBDLast updated:

Trial Snapshot

Phase
未知
Status
Not yet recruiting
Sponsor
Enrollment
100

Study Overview

Brief Summary

No summary available.

Study Design

Study Type
Interventional

Eligibility Criteria

Inclusion Criteria

  • Women with one high risk factor / two or more moderate risk factors as given below
  • High risk factors:
  • 1. Previous pregnancy with h/o hypertensive disorders (pre-eclampsia, eclampsia, gestational hypertension, chronic hypertension), IUGR, abruption.
  • 2. Chronic hypertension
  • 3.Chronic kidney disease
  • 4. Autoimmune diseases such as SLE, antiphospolipid antibody syndrome.
  • Moderate risk factors:
  • 1.First pregnancy
  • 2.Pregnancy interval > 10 years
  • 3.BMI >35/m2 at first visit
  • 4.Age >40 years
  • 5.Family h/o Pre eclampsia.

Exclusion Criteria

  • 1. Women with h/o heart disease (congenital heart disease, valvular heart disease, ischemic heart disease)
  • 2. Women with Hb < 8 g/dl
  • 3. Multi-fetal gestations
  • 4. Diabetes, Chronic Renal/Liver disease, Epilepsy
  • 5. Women with history of allergy to ISMN

Investigators

Sponsor
Jawaharlal Institute of Post graduate Medical Education and Research

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