Pocus based fluid tolerance score as a predictor of end organ dysfunction and mortality in patients with sepsis- a prospective observational study
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 149
- 试验地点
- 1
- 主要终点
- To correlate pocus based fluid tolerance score with end organ dysfunction and mortality
研究概览
简要总结
Excessive fluid resuscitation in septic shock causes venous congestion, that in turn contribute to poor clinical outcome and end organ dysfunction. So the focus of attention has to be changed from forward flow assessment (cardiac output and microcirculatory parameters) to venous congestion assessment and organ function.
Concept of fluid tolerance will help to bridge the gap between fluid responsiveness and fluid overload. POCUS based parameters will be able to pick up early signs of venous congestion that lead to fluid intolerance. There is lacunae in literature to correlate the relationship of fluid tolerance and their relation to end organ dysfunction.
Hence a pocus parameters based fluid tolerance score has been constructed and we are analyzing correlation between this fluid tolerance score with end organ dysfunction and mortality in septic shock patients.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 99.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients aged above 18 years, admitted to MICU with sepsis/septic shock.
排除标准
- •Severe MR, AR
- •Pregnancy
- •Prosthetic, transplant heart.
结局指标
主要结局
To correlate pocus based fluid tolerance score with end organ dysfunction and mortality
时间窗: Baseline, every 48 hours until ICU discharge
in septic shock patients.
时间窗: Baseline, every 48 hours until ICU discharge
次要结局
- To evaluate the incidence of organ dysfunction in adult septic patients with systemic venous congestion.
研究者
Dr Arshad N N
Narayana Health