Pocus based fluid tolerance score as a predictor of end organ dysfunction and mortality in patients with sepsis- a prospective observational study
Overview
- Phase
- Not Applicable
- Status
- Not yet recruiting
- Sponsor
- Dr Arshad N N
- Enrollment
- 149
- Locations
- 1
- Primary Endpoint
- To correlate pocus based fluid tolerance score with end organ dysfunction and mortality
Overview
Brief Summary
Excessive fluid resuscitation in septic shock causes venous congestion, that in turn contribute to poor clinical outcome and end organ dysfunction. So the focus of attention has to be changed from forward flow assessment (cardiac output and microcirculatory parameters) to venous congestion assessment and organ function.
Concept of fluid tolerance will help to bridge the gap between fluid responsiveness and fluid overload. POCUS based parameters will be able to pick up early signs of venous congestion that lead to fluid intolerance. There is lacunae in literature to correlate the relationship of fluid tolerance and their relation to end organ dysfunction.
Hence a pocus parameters based fluid tolerance score has been constructed and we are analyzing correlation between this fluid tolerance score with end organ dysfunction and mortality in septic shock patients.
Study Design
- Study Type
- Observational
Eligibility Criteria
- Ages
- 18.00 Year(s) to 99.00 Year(s) (—)
- Sex
- All
Inclusion Criteria
- •Patients aged above 18 years, admitted to MICU with sepsis/septic shock.
Exclusion Criteria
- •Severe MR, AR
- •Pregnancy
- •Prosthetic, transplant heart.
Outcomes
Primary Outcomes
To correlate pocus based fluid tolerance score with end organ dysfunction and mortality
Time Frame: Baseline, every 48 hours until ICU discharge
in septic shock patients.
Time Frame: Baseline, every 48 hours until ICU discharge
Secondary Outcomes
- To evaluate the incidence of organ dysfunction in adult septic patients with systemic venous congestion.
Investigators
Dr Arshad N N
Narayana Health