Is Involucrin Has a Role in Verruca Vulgaris? A Clinical and Immunohistochemical Study
- Registration Number
- NCT04793529
- Lead Sponsor
- Benha University
- Brief Summary
Vitamin D3 plays important role in keratinocyte differentiation and had been used recently in verruca vulgaris. Aim of the work: To assess the expression of involucrin in verrucae vulgaris before and after injection of vitamin D3. Subjects and Methods: This study included 60 patients with verrucae vulgaris subjected to intralesional injection of vitamin D3 at three weeks interval for a maximum of five sessions. Immunohistochemical assessment of involucrin was done before and after injection and compared to skin biopsies from 30 healthy individuals
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 60
Not provided
Patients with a past history of allergic response to vitamin D. Pregnant or lactating females. Hepatic patients. Renal patients. Patients with bleeding tendency.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Cholecalciferol injection Cholecalciferol -
- Primary Outcome Measures
Name Time Method Resolution of verrucae 3 months Decrease of verrucae size Decrease of verrucae number
- Secondary Outcome Measures
Name Time Method Involucrin expression 3 months Change of expression pattern of involucrin by immunohistochemical study Change of expression grade of involucrin by immunohistochemical study
Trial Locations
- Locations (1)
Essam Mohamed El-sayed Akl
🇪🇬Banhā, Egypt
Essam Mohamed El-sayed Akl🇪🇬Banhā, Egypt