Study on the Carcinogenesis of SOX-9 in Oral Cancer, and Chemopreventive Possibility for the Treatment of Oral Cancer.

• Conditions: Oral Cancer; Carcinogenesis

• Registration Number: NCT01919567
• Lead Sponsor: National Taiwan University Hospital

Brief Summary

Study on the Carcinogenesis of SOX-9 in Oral Cancer, and Chemopreventive Possibility for the Treatment of Oral Cancer Using SOX-9 Inhibitor.

Detailed Description

To find out if there is prognostic value which to the performance of SOX-9 of oral cancer in Taiwan and provide some reference for future treatment.

We anticipate to enroll 40 persons with normal oral mucosa, 65 persons with oral dysplasia and 150 persons with oral cancer and collect the tissue which was stained for pathological sections over a 3 year period.

We also collect the blood and saliva samples from patients and the results along with patient-specific information such as tumor phases, tumor size, lymph node metastasis, cancer metastasis, prognosis and betel nut chewing, smoking and drinking habits and other parameters are statistically analyzed.

Study Timeline

• Study Start: 2011-11
• Study First Submitted: 2013-08-07
• Study First Submitted QC: 2013-08-08
• Study First Posted: 2013-08-09
• Status Verified: 2013-11
• Last Update Submitted: 2013-12-08
• Last Update Posted: 2013-12-10
• Primary Completion: 2014-04
• Study Completion: 2014-04

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 255

Inclusion Criteria

• Dysplasia or cancer of the oral cavity.

Exclusion Criteria

• pregnant woman

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Carcinogenesis of SOX-9	3 years

Trial Locations

Locations (1)

National Taiwan University Hospital research Ethics Committee; 🇨🇳 Taipei, Taiwan