NCT02704910终止不适用
Lateral Postural Inclination in Parkinson's Disease : Involvement of the Basal Ganglia ?
University Hospital, Grenoble2 个研究点 分布在 1 个国家目标入组 38 人开始时间: 2012年1月1日最近更新:
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 发起方
- 入组人数
- 38
- 试验地点
- 2
- 主要终点
- Lateropulsion measured by computerized Posturography
研究概览
简要总结
The objective of this study is to assess the origins of lateral postural inclination presented by some Parkinson disease's patients.
Several mechanisms could cause lateral postural inclination. Available data allow to suggest three hypothesis: (troubles of tonus, perception of vertical perturbation, trouble of perception of corporal axis
详细描述
Inclusion Criteria:
- 30 to 75 years old patient
- Parkinson disease's diagnosed since 5 years
- Treated by deep brain stimulation
- Patient with at least 6 degree lateral deviation
- Without vestibular troubles nor peripheral sensorial trouble.
Exclusion Criteria:
- Dementia (Mattis < 130 ou MMS <24), or severe depressive episode according to DSM IV-R criteria
- Camptocormia or incompatible anteflexion with the dispositive of measure device
- Pregnant woman, nursing mother
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 30 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •30 to 75 years old patient
- •Parkinson disease's diagnosed since 5 years
- •Treated by deep brain stimulation
- •Patient with at least 6 degree lateral deviation
- •Without vestibular troubles nor peripheral sensorial trouble.
排除标准
- •Dementia (Mattis < 130 ou MMS <24), or severe depressive episode according to DSM IV-R criteria
- •Camptocormia or incompatible anteflexion with the dispositive of measure device
- •Pregnant woman, nursing mother
研究组 & 干预措施
Voluntary subject
Placebo Comparator
Patient without parkinson disease, without deep brain stimulation
干预措施: Subthalamic stimulation (Behavioral)
Patients
Active Comparator
Subthalamic stimulation
干预措施: Subthalamic stimulation (Behavioral)
结局指标
主要结局
Lateropulsion measured by computerized Posturography
时间窗: 4 days
The postural inclination is measured in two conditions: With and without Deep Brain Stimulation. (Gissot et al., 2007).
次要结局
未报告次要终点
研究者
研究点 (2)
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