The Impact of FGF23 and Klotho on Progression of Chronic Kidney Disease

Ankara Education and Research Hospital1 个研究点分布在 1 个国家目标入组 90 人开始时间: 2008年3月最近更新: 2011年3月17日

适应症

试验速览

阶段: 不适用
发起方
入组人数: 90
试验地点: 1
主要终点: Progression of kidney disease

研究概览研究设计入排标准结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

Chronic kidney disease is a progressive disorder that has been influenced with many factors. Most of the patients has altered Ca P metabolism and these dis orders are the contributing factors of the disease progression. It has been recently documented that FGF23 and Klotho are the key factors of PTH secretion Ca-P metabolism. This study aimed to evaluate the impact of Klotho and FGF23 on the progression of stage 3-4 chronic kidney disease.

研究设计

研究类型: Observational
观察模型: Cohort
时间视角: Prospective

入排标准

年龄范围: 18 Years 至 65 Years（Adult, Older Adult）
性别: All
接受健康志愿者: 否

入选标准

•Non-diabetic chronic kidney disease

排除标准

•Presence of DM
•Actively using calcium based phosphorus binder of vitamin D

结局指标

主要结局

Progression of kidney disease

时间窗: continuous measurement of kidney functions 3 monthly for two years or until the outcome reached

Doubling of creatinin, requirement of renal replacement therapy

次要结局

Evaluation of Ca P metabolism(3 monthly for two years or until the outcome reached)

研究者

发起方

Ankara Education and Research Hospital

申办方类型

Other Gov

研究点 (1)

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