Effect of Low-level Laser Therapy on Post-bleaching Sensitivity and Color Change

Not Applicable

Completed

• Conditions: Low-level Laser Therapy; Dentin Sensitivity; Clinical Trial; Tooth Bleaching
• Interventions: Radiation: Low-lever laser; Other: Tooth bleaching; Other: Placebo

• Registration Number: NCT03514290
• Lead Sponsor: Universidade Federal do Para

Brief Summary

Objective: The objective of this clinical study was to evaluate low-level laser (LLL) therapy in tooth sensitivity and in effecting color change after in-officer bleaching treatment across three weeks of treatment.

Methods: Twenty-one volunteers were evaluated through the split-mouth model, so that the right and left maxillary/mandibular quadrants were randomized and allocated to one of two groups: GPLACEBO - the laser tip was positioned without the emission of light (placebo effect) + tooth bleaching with 35% hydrogen peroxide (HP); GLASER - treated with LLL + tooth bleaching with 35% HP. To assess tooth sensitivity, a modified visual analogue scale (VAS) was used after an evaporative stimulus (stimulated pain) and a daily pain questionnaire (unstimulated pain) was also applied. A spectrophotometer was used to measure the color. Three bleaching sessions were performed, with intervals of 7 days. Sensitivity results were tested using Friedman test for intra-group evaluation and Wilcoxon test for inter-group evaluation and ANOVA for color change.

Detailed Description

Twenty-one volunteers were evaluated through the split-mouth model, so that the right and left maxillary/mandibular quadrants were randomized and allocated to one of two groups: GPLACEBO - the laser tip was positioned without the emission of light (placebo effect) + tooth bleaching with 35% hydrogen peroxide (HP); GLASER - treated with LLL + tooth bleaching with 35% HP. To assess tooth sensitivity, a modified visual analogue scale (VAS) was used after an evaporative stimulus (stimulated pain) and a daily pain questionnaire (unstimulated pain) was also applied. A spectrophotometer was used to measure the color. Three bleaching sessions were performed, with intervals of 7 days.

Study Timeline

• Study Start: 2016-07-11
• Primary Completion: 2016-08-08
• Study Completion: 2016-09-30
• Study First Submitted: 2018-03-15
• Status Verified: 2018-04
• Study First Submitted QC: 2018-04-30
• Last Update Submitted: 2018-04-30
• Study First Posted: 2018-05-02
• Last Update Posted: 2018-05-02

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 21

Inclusion Criteria

• Do not have previous dental sensitivity
• The canine had to be shade A2 or darker.

Exclusion Criteria

• Enamel hypoplasia
• Gingival recession
• Dentin exposure
• Visible cracks on buccal enamel
• Pulpitis

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
GLASER	Tooth bleaching	treated with Low-lever laser + tooth bleaching with 35% hydrogen peroxide (HP).
GPLACEBO	Tooth bleaching	the laser tip was positioned without the emission of light (placebo effect) + tooth bleaching with 35% hydrogen peroxide (HP).
GPLACEBO	Placebo	the laser tip was positioned without the emission of light (placebo effect) + tooth bleaching with 35% hydrogen peroxide (HP).
GLASER	Low-lever laser	treated with Low-lever laser + tooth bleaching with 35% hydrogen peroxide (HP).

Primary Outcome Measures

Name	Time	Method
Dental sensitivity induced by office bleaching	change in baseline sensitivity at the 3rd bleaching session	Evaporative stimulus (stimulated pain) using air jet from a triple syringe and a daily pain questionnaire (unstimulated pain). Both methods were associated with a modified visual analogue scale was used: 0 (pain absent); 1 (mild pain); 2 (moderate pain) and 3 (severe pain).

Secondary Outcome Measures

Name	Time	Method
Color change promoted by tooth bleaching	change in baseline color at the 3rd bleaching session	Spectrophotometer was used to measure the color

Trial Locations

Locations (1)

Federal University of Pará; 🇧🇷 Belém, PA, Brazil