Effect of pentoxifylline use on cardiac function in patients with chagasic cardiomyopathy

Not Applicable

• Conditions: Chagas disease; chronic chagasic cardiomyopathy; cardiac arrhythmias; C14.280.067; C03.752.300.900.200.190; C03.752.300.900.200

• Registration Number: RBR-8k345j
• Lead Sponsor: Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2019-12-13
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Recruitment completed
• Sex: Not specified
• Target Recruitment: Not specified

Inclusion Criteria

The patients will be recruited from the population already attended at the specialized outpatient clinics of the Cardiology Center of the University of Ribeirão Preto Medical School Hospital das Clínicas. The study will include patients with a diagnosis of chronic chagasic heart disease confirmed by two distinct serological tests indirect immunofluorescence and enzyme immunoabsorption assay showing typical left ventricular segmental parietal mobility changes evidenced by transthoracic echocardiography that characterize chronic myocardial involvement by the disease. Study participants should have preserved left ventricular ejection fraction or with a slight reduction greater than 35%, may exhibit mild symptoms of heart failure

Exclusion Criteria

Patients with another etiology for myocardial dysfunction such as alcoholism will be excluded, previous myocardial infarction, known coronary artery disease, use of cardiotoxic or illicit drugs and peripartum cardiomyopathy, primary valvular heart disease and pericardial disease. Patients with comorbidities that compromise functional capacity such as severe chronic obstructive pulmonary disease will also be excluded; severe liver disease; collagenosis, untreated thyroid dysfunction. Coronary artery disease should be excluded by cardiac catheterization in those patients with ischemic perfusion defects on myocardial perfusion scintigraphy who exhibit 2 or more risk factors for atherosclerotic coronary artery disease

Study & Design

• Study Type: Intervention
• Study Design: Not specified