Diaphragm Ultrasound to Predict Posteroperative Residual Blockade

• Conditions: Ultrasonography; Residual Curarization

• Registration Number: NCT04321681
• Lead Sponsor: Peking Union Medical College Hospital

Brief Summary

This study is a prospective observational research approved by the Ethics Committee of the Peking Union medical college Hospital. Patients scheduled for elective non-abdominal and non-thoracic surgery among age of 19-65 years and American Society of Anesthesiologists Physical Status Classification(ASA) I or II were inrolled. Diaphragm ultrasonogram was measured pre and post operation. Diaphragm excursion and diaphragm thickening fraction during quiet breathing as well as deep breathing were assessed. Neuromuscular monitor was performed during operation, after proper calibration.

Detailed Description

Not available

Study Timeline

• Study Start: 2019-06-01
• Status Verified: 2020-03
• Study First Submitted: 2020-03-18
• Study First Submitted QC: 2020-03-24
• Last Update Submitted: 2020-03-24
• Study First Posted: 2020-03-25
• Last Update Posted: 2020-03-25
• Primary Completion: 2020-04-30
• Study Completion: 2020-04-30

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 75

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Diaphragm ultrasound parameter	within 1 min after extubation	Diaphragm excursion and thickening fraction was measured through ultrasonography within 2 min after extubation. Correlation between TOFr ratio and diaphragm parameters was explored.
TOFr at extubation	within1 min before extubation	Neuromuscular function was monitored thoughout operation based neuromuscular monitoring guideline by an independent investigator. TOF ratio before extubation was recorded. The scale of TOFr range from 0 to 1. TOFr\<0.9 indicate existance of residual neuromuscular blockade.

Secondary Outcome Measures

Name	Time	Method
Posteroperative pulmonary complication	1 month	incidence of airway obstruction, bronchospasm, pulmonary aspiration of gastric contents, apnea, unexpected ICU admissions, atelectasis and pneumonia
reintubation rate	within 24 hour	If patients cannot breath by themselves after extubation, They need to be reintubated and mechanical ventilation need to be use to sustain their breathing.

Trial Locations

Locations (1)

Department of Anesthesiology, Peking Union Medical College Hospital; 🇨🇳 Beijing, Beijing, China