Cellular Immune Responses in Triple-negative Breast Cancer - High Throughput Immunogenetic Studies
试验速览
- 阶段
- 不适用
- 状态
- Enrolling By Invitation
- 发起方
- 入组人数
- 150
- 试验地点
- 1
- 主要终点
- T cell receptor profiling as a potential biomarker in Triple-Negative Breast Cancer
研究概览
简要总结
This project introduces a novel methodology for the in-depth immunogenetic characterization of the TR gene repertoire in solid tumors, holding the promise to offer unprecedented insights into the TR anti-tumor specificity and the prognostic/predictive value of TR gene repertoire signatures.
详细描述
The goal of this observational study is to address the role of T cells in the tumor microenvironment of TNBC.
In detail, this study aims to:
(i) explore the immunogenetic characteristics of the TR gene repertoire as informative prognostic/predictive biomarkers in TNBC (ii) identify immunogenic neoepitopes arising from common tumor-specific non-synonymous gene mutations, as well as the corresponding neoepitope-specific T cells (iii) describe, in single-cell resolution, the spatial organization of the intricate crosstalk between tumor cells and neoepitope specific-T cells, and (iv) delineate the functional properties of T cells within the TME.
All the experimental results, regarding the TR repertoire features and the spatial organization of the TME, will be correlated with clinical outcome measurements (e.g. overall survival, progression time), which are available from the detailed patients medical record.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Confirmed TNBC diagnosis
排除标准
- 未提供
结局指标
主要结局
T cell receptor profiling as a potential biomarker in Triple-Negative Breast Cancer
时间窗: 4 years
次要结局
未报告次要终点