Antibiotic prophylaxis with doxycycline vs azithromycin prior to hysterosalpingography

Phase 4

Conditions: pelvic inflammatory disease.
Female pelvic inflammatory disease, unspecified
N73.9

Registration Number: IRCT20190219042755N1

Lead Sponsor: Arak University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Complete

Sex: Female

Target Recruitment: 180

Inclusion Criteria

Sub fertile women 15-35 year old
Do not take any antibiotics during the week before the procedure

Exclusion Criteria

History of severe drug allergy to doxycycline and azithromycin (anaphylactic shock, cutaneous rash, and complications leading to hospitalization)
Active pelvic inflammation
Previously known history of pelvic infection
Known case of endometriosis
History of ectopic pregnancy
History of fallopian tube surgery
Pregnancy
Severe uterine bleeding

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Pelvic inflammatory disease is defined as a clinical diagnosis including fever and chills. Vaginal discharge. Abdominal pain. Timepoint: Evaluation of patients' symptoms for pelvic inflammatory infection 2 weeks after hysterosalpingography and in case of patients with symptoms of pelvic inflammatory infection , Follow up patients for the next 2 weeks after symptoms resolve. Method of measurement: Visit the doctor by phone and check the patient's symptoms and if any of the symptoms are fever and chills, vaginal discharge and hypogastric pain, see a gynecologist and after examining the patient and prescribing appropriate treatment, follow up patients for 2 weeks until complete relief of symptoms.

Secondary Outcome Measures

Name	Time	Method
Drug side effects, nausea and vomiting. Timepoint: Within two weeks after hysterosalpingography. Method of measurement: Phone call by the doctor and questions from the patient.;Drug side effects, diarrhea. Timepoint: Within two weeks after hysterosalpingography. Method of measurement: Phone call by the doctor and questions from the patient.;Drug side effects, abdominal pain. Timepoint: Within two weeks after hysterosalpingography. Method of measurement: Phone call by the doctor and questions from the patient.