A phase III randomized sequential open-label study to evaluate the efficacy and safety of sorafenib followed by sunitinib versus sunitinib followed by sorafenib in the treatment of first-line advanced / metastatic renal cell carcinoma
- Conditions
- First-line advanced / metastatic renal cell carcinomaMedDRA version: 16.0Level: PTClassification code 10050513Term: Metastatic renal cell carcinomaSystem Organ Class: 10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)Therapeutic area: Diseases [C] - Cancer [C04]
- Registration Number
- EUCTR2008-005011-18-AT
- Lead Sponsor
- Deutsche Krebsgesellschaft Sponsor GmbH
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Recruiting
- Sex
- All
- Target Recruitment
- 346
1.Patients with metastatic / advanced RCC (all histologies), who are not suitable for cytokine therapy and for whom study medication constitutes first-line therapy
2.Age >= 18 years and <= 85 years
3.ECOG Performance Status of 0 or 1
4.MSKCC (1999) prognostic score, low or intermediate
5.Life expectancy of at least 12 weeks.
6.Subjects with at least one uni-dimensional (for RECIST) measurable lesion. Lesions must be measured by CT/MRI-scan.
7.Adequate bone marrow, liver and renal function as assessed by the following laboratory requirements to be conducted within 7 days prior to start of therapy:
- Hemoglobin > 9.0 g/dl
- Absolute neutrophil count (ANC) >1,500/mm3
- Platelet count ? 100,000/µl
- Total bilirubin < 1.5 times the upper limit of normal
- ALT and AST < 2.5 x upper limit of normal (< 5 x upper limit of normal
for patients with liver involvement of their cancer)
- Alkaline phosphatase < 4 x upper limit of normal
- PT-INR/PT < 1.5 x upper limit of normal [Patients who are being
therapeutically anticoagulated with an agent such as coumadin or
heparin will be allowed to participate provided that no prior evidence of
underlying abnormality in these parameters exists.]
- Serum creatinine
8. Written Informed Consent
Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range
F.1.3 Elderly (>=65 years) yes
F.1.3.1 Number of subjects for this age range
1.History of cardiac disease: congestive heart failure >NYHA class 2 or with LVEF at baseline echocardiography <50%; active CAD (MI more than 6 months prior to study entry is allowed); cardiac arrhythmias requiring anti-arrhythmic therapy (beta blockers or digoxin are permitted) or uncontrolled hypertension (defined as blood pressure >= 160 mmHg systolic and/or >= 90 mmHg diastolic on medication).
2.History of HIV infection or chronic hepatitis B or C
3.Active clinically serious infections (> grade 2 NCI-CTC version 3.0)
4.Symptomatic metastatic brain or meningeal tumors (unless the patient is > 6 months from definitive therapy, has a negative imaging study within 4 weeks of study entry and is clinically stable with respect to the tumor at the time of study entry)
5.Patients with seizure disorder requiring medication (such as steroids or anti-epileptics)
6.History of organ allograft
7.Patients with evidence or history of bleeding diathesis
8. Untreated hypothyrosis
9. Patients undergoing renal dialysis
10.Previous or concurrent cancer that is distinct in primary site or histology from the cancer being evaluated in this study EXCEPT cervical carcinoma in situ, treated basal cell carcinoma, superficial bladder tumors [Ta, Tis & T1] or any cancer curatively treated > 3 years prior to study entry.
11.Pregnant or breast-feeding patients. Women of childbearing potential must have a negative pregnancy test performed within 7 days of the start of treatment. Both men and women enrolled in this trial must use adequate barrier birth control measures during the course of the trial and 3 months after the completion of trial.
12.Substance abuse, medical, psychological or social conditions that may interfere with the patient’s participation in the study or evaluation of the study results
13.Any condition that is unstable or could jeopardize the safety of the patient and their compliance in the study
14.Patients unable to swallow oral medications
15.Known allergy to sunitinib or sorafenib or one of its constitutents
Excluded therapies and medications, previous and concomitant:
1. Anticancer chemotherapy or immunotherapy before study entry or during the study.
2. Radiotherapy during study or within 3 weeks of start of study drug. (Palliative
radiotherapy will be allowed). Major surgery within 4 weeks of start of study
3. Autologous bone marrow transplant or stem cell rescue within 4 months of study
4. Use of biologic response modifiers, such as G-CSF, within 3 week of study entry.
[G-CSF and other hematopoietic growth factors may be used in the management
of acute toxicity such as febrile neutropenia when clinically indicated or at the
discretion of the investigator; however they may not be substituted for a required
dose reduction.] [Patients taking chronic erythropoietin are permitted provided no
dose adjustment is undertaken within 2 months prior to the study or during the
study]
5. Investigational drug therapy outside of this trial during or within 4 weeks of study
entry
6. Prior exposure to the study drug.
7. Any St. John’s wort containing remedy
Study & Design
- Study Type
- Interventional clinical trial of medicinal product
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method