Transcranial Direct Current Stimulation(tDCS) machine is entirely non-invasive and very safe, which delivers 2mA of direct current to the brain, which may leads to improvement in symptoms of OCD in patient with treatment resistant Obsessive Compulsive Disorder(OCD).
- Conditions
- Mixed obsessional thoughts and acts, treatment resistant OCD,
- Registration Number
- CTRI/2017/02/007775
- Lead Sponsor
- Office of Department of PsychiatryAll India Institute of Medical Sciences
- Brief Summary
Primary Purpose:-Only 40-60% of patients with OCD respond to currently available pharmacotherapy. Brain stimulation therapies report encouraging results with neuromodulation modalities in treatment resistant OCD. tDCS can act as a potential neuromodulator in treatment resistant OCD. Hypothesis:-In individuals suffering from treatment resistant OCD, application of cathodal tDCS over supplementary motor area (SMA) as an add-on to pharmacotherapy will improve OC symptoms.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 20
1-Right handed (assessed by Edinburgh’s Handedness Inventory) 2-Patients with OCD (diagnosed on ICD-10) 3-Meets criteria for treatment resistant as per ITROC (level 1 non-response) 4-YBOCS score ≥ 16(moderate severity) 5-Willing to give written informed consent to participate in the study.
1-Presence of co-morbid Axis I disorders (using MINI 5.0) including substance abuse/dependence (except caffeine or nicotine) 2-History of seizure 3-History of receiving rTMS/ECT treatment 4-History suggestive of space occupying brain lesion or cerebro-vascular accident 5-Presence of chronic medical illness 6-Having implanted device or metals in brain/head or cardiac pacemaker 7-Known or suspected pregnancy or currently lactating 8-Having imminent suicide risk 9-Having score of ≥ 17 on HAM-D.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 35% or more reduction in the YBOCS score After completion of 20 sessions of tDCS
- Secondary Outcome Measures
Name Time Method score of 2 or less (much or very much improved) After completion of 20 sessions of tDCS
Trial Locations
- Locations (1)
Rajkumari Amrit Kaur OPD,Department of Psychiatry, 2nd floor, room no 11, AIIMS main building
🇮🇳West, DELHI, India
Rajkumari Amrit Kaur OPD,Department of Psychiatry, 2nd floor, room no 11, AIIMS main building🇮🇳West, DELHI, IndiaDr Satish KumarPrincipal investigator9711174678nmc.satish@gmail.com