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临床试验/NCT06249035
NCT06249035招募中不适用

Feasibility of Transesophageal Echocardiography in Patients With Cardiac Arrest in Emergency Departments in the Netherlands

Frisius Medisch Centrum2 个研究点 分布在 1 个国家目标入组 30 人开始时间: 2024年6月25日最近更新:
适应症

试验速览

阶段
不适用
状态
招募中
发起方
入组人数
30
试验地点
2
主要终点
Area of maximal compression (AMC)

研究概览

简要总结

The goal of this feasibility study is to learn if Dutch ED providers are able to use transesophageal echocardiography during cardiac arrest.

The main question it aims to answer is:

• are the ED providers able to determine the area of maximal compression of the heart using TEE

详细描述

Point-of-care ultrasound is a valuable diagnostic tool during cardiopulmonary resuscitation (CPR) in cardiac arrest and its use is recommended by international guidelines. Transthoracic echocardiography (TTE) is most commonly used, but has certain limitations. Image acquisition can be challenging due to patient specific factors such as body habitus. Also image quality may be impacted by the limited acquisition time during CPR pulse checks. Furthermore, observational data suggests that pulse checks are prolonged due to TTE, while minimizing interruption of chest compressions is emphasized for better CPR outcomes in the guidelines. Transesophageal ultrasound (TEE) is a possible alternative for TTE. It has the theoretical advantage of superior image quality and thereby possible reductions of chest compression delays. Furthermore, TEE gives the opportunity determine which part of the heart is compressed most effectively, which is referred to as the area of maximal compression (AMC). Animal studies showed that an AMC located over the left ventricle positively influenced hemodynamics and return of spontaneous circulation (ROSC) compared to an AMC over the aortic root. In human studies, data also suggests that AMC located on the left ventricle, as measured by TEE, may positively influence prognosis.

In the Netherlands, TEE is currently not used in emergency departments during cardiac arrest. The purpose of this study is to investigate if point-of-care TEE can be used effectively and safely by providers and teams that have not previously used this modality. Given the paramount importance of quality of chest compressions, the ability of the providers to assess the location of the AMC will be the main focus of this feasibility study.

研究设计

研究类型
Interventional
分配方式
Na
干预模型
Single Group
主要目的
Diagnostic
盲法
None

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Patients with cardiac arrest > 18 year in the emergency department.

排除标准

  • Patients with known upper gastro-intestinal malignancy or strictures, previous upper gastro-intestinal surgery or radiation, or known esophageal varices.
  • Patient with a do-not-resuscitate order, pregnant patients and traumatic cardiac arrest.
  • No trained TEE provider available.
  • ROSC at arrival.
  • Decision by the team to stop resuscitation at arrival at the emergency department due of prognosis.
  • Other life saving interventions which are prioritized over TEE by the resuscitation team.

结局指标

主要结局

Area of maximal compression (AMC)

时间窗: First 30 minutes of cardiac arrest treatment in the ED.

The percentage of patients in which providers are able to determine the location of the AMC during cardiac arrest.

次要结局

  • Time to image(First 30 minutes of cardiac arrest treatment in the ED.)
  • Safety of TEE(First 30 minutes of cardiac arrest treatment in the ED.)
  • Location of AMC(First 30 minutes of cardiac arrest treatment in the ED.)
  • Accuracy of AMC(First 30 minutes of cardiac arrest treatment in the ED.)
  • Intubation(First 30 minutes of cardiac arrest treatment in the ED.)

研究者

发起方
Frisius Medisch Centrum
申办方类型
Other
责任方
Sponsor

研究点 (2)

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