Bifidobacterium Animalis Subsp. Lactis in Prevention of Common Infections in Healthy Children Attending Day Care Centers - Randomized, Double Blind, Placebo Controlled Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 250
- 试验地点
- 2
- 主要终点
- Common infections
研究概览
简要总结
Hypothesis: Use of Bifidobacterium animalis subsp. lactis can effectively prevent common infections (gastrointestinal and respiratory) in healthy children who attend day care centre
This study is a prospective, randomized, double blind, placebo- controlled parallel study in healthy children attending day care centers.
The study will investigate the effect of supplementation with the probiotic strain Bifidobacterium animalis subsp. lactis on the incidence and duration of gastrointestinal and respiratory infections and absence from day care due to infections.
The test product is a sachet containing 1 gram of powder. The test product will contain minimum 1 billion CFU (colony forming units) of probiotic per serving. The placebo product is an identical product except for the absence of probiotics.
The study includes 3 months (90 days) of intervention period. The study product will be consumed daily in the evening together with a meal.
The consumption of the study products will be taken under the surveillance of the parents.
During the entire intervention period the subjects are not allowed to consume any probiotic products other than the study products supplied to them by the study personnel.
Data on infections will be recorded in a diary, filled in and administered by the parents and diary recorded by referring physician (on-call log).
All infections are to be diagnosed by the local physician. The incidence of infections will be analyzed based on the information recorded in the diaries (parent's & physician's).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 1 Year 至 7 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Healthy children attending day care at kindergartens located in the Zagreb's city centre
- •Age from 1 year to 7 years
- •Attendance at daycare centers: > 3 days per week
- •Signed informed consent by the parents
排除标准
- •Immunodeficiency
- •Receiving probiotic and /or prebiotic products prior to enrolment (2 weeks prior to study start)
- •Neoplasms
- •Severe chronic disorders
结局指标
主要结局
Common infections
Number of children with gastrointestinal tract infections defined as diarrhoea (3 or more loose or watery stools in 24 hours or increase of number of stools for more than 50% in 24 hours) or vomiting (defined by physician and not a result of other symptoms including cough or diseases including gastroesophageal reflux disease or neurological conditions) or both. And number of children with respiratory tract infections defined as: pharyngitis, otitis, common cold, pneumonia, bronchitis and bronciolitis (all infections diagnosed by physician) Number of children with adverse events.
次要结局
- Duration of symptoms