Can 4 Weeks of Exercise Program Change Quadriceps Architecture in Patients With Rheumatoid Arthritis

Not Applicable

Completed

• Conditions: Quadriceps Muscle Atrophy; Arthritis, Rheumatoid; Exercise; Ultrasonography; Knee Osteoarthritis

• Registration Number: NCT04834050
• Lead Sponsor: Ovgu Bickici

Brief Summary

Quadriceps femoris (QF) atrophy is seen in rheumatoid arthritis and knee osteoarthritis (OA) patients. Exercise therapy is mile stone in knee OA patients also it can help thicken QF muscle of RA patients. We primarily aimed to demonstrate the influence of 4 weeks of knee isometric home-based training on QF muscle parts thickness and pennation angle measurements of RA patients with ultrasonography (USG). This study included 12 patients with RA, 12 patients with knee OA as positive control group and 13 volunteers as healthy control group. All participants were given 4 weeks of quadriceps-hamstring isometric home-based training. At baseline and at the end of the program, WOMAC and Lequesne algofunctional index scores of knee OA patients and DAS28-CRP scores of RA patients were recorded. Dominant knee thickness and pennation angle measurements of QF muscle parts were evaluated by ultrasonography.

Detailed Description

Not available

Study Timeline

• Study Start: 2018-10-01
• Primary Completion: 2019-06-12
• Study Completion: 2020-02-20
• Study First Submitted: 2021-03-31
• Status Verified: 2021-04
• Study First Submitted QC: 2021-04-05
• Last Update Submitted: 2021-04-05
• Study First Posted: 2021-04-06
• Last Update Posted: 2021-04-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 37

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Change of quadriceps femoris parts thickness measures	At baseline and after 4 weeks of intervention	Dominant knee vastus lateralis, medialis, intermedius and rectus femoris thicknesses of 3 groups were calculated at baseline and at the end of intervention.
Change of quadriceps femoris parts pennation angles	At baseline and after 4 weeks of intervention	Pennation angles of vastus lateralis, medialis and intermedius were calculated at baseline and at the end of exercise program.

Secondary Outcome Measures

Name	Time	Method
Change of The Western Ontario and McMaster Universities Arthritis Index (WOMAC) score of knee OA	At baseline and after 4 weeks of intervention	The Western Ontario and McMaster Universities Arthritis Index (WOMAC) scores of knee OA patients were calculated at baseline and at the end of exercise program. The Western Ontario and McMaster Universities Arthritis Index (WOMAC) is divided into 3 subscales: Pain, stiffness, physical function. The scores for each subscale are summed up, with a possible score range of 0-20 for Pain, 0-8 for Stiffness, and 0-68 for Physical Function. A sum of scores of 3 subscales were multipled with 100 and divided by 96 and resulted in WOMAC score of the patients.; Higher scores on the WOMAC indicate worse pain, stiffness, and functional limitations.
Change of Disease activity score 28-C reactive protein (DAS28-CRP)	At baseline and after 4 weeks of intervention	Disease activity score 28-C reactive protein (DAS28-CRP) scores of RA patients were calculated at baseline and at the end of program. A score lower than 2.6 means remission, score between 2.6 and 3.2 means low disease activity, score between 3.2 and 5.1 means moderate disease activity and score higher than 5.1 means high disease activity.
Change of Lequesne scores of knee OA patients	At baseline and after 4 weeks of intervention	Lequesne algofunctional index scores of knee OA patients were calculated at baseline and at the end of the intervention. The Lequesne OA index is scored as the sum of questions ranging from 0 to 24, higher scores meaning worse outcome.

Trial Locations

Locations (1)

Gazi University Faculty of Medicine; 🇹🇷 Ankara, Turkey