Can 4 Weeks of Exercise Program Change Quadriceps Architecture in Patients With Rheumatoid Arthritis
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Arthritis, Rheumatoid
- Sponsor
- Ovgu Bickici
- Enrollment
- 37
- Locations
- 1
- Primary Endpoint
- Change of quadriceps femoris parts thickness measures
- Status
- Completed
- Last Updated
- 5 years ago
Overview
Brief Summary
Quadriceps femoris (QF) atrophy is seen in rheumatoid arthritis and knee osteoarthritis (OA) patients. Exercise therapy is mile stone in knee OA patients also it can help thicken QF muscle of RA patients. We primarily aimed to demonstrate the influence of 4 weeks of knee isometric home-based training on QF muscle parts thickness and pennation angle measurements of RA patients with ultrasonography (USG). This study included 12 patients with RA, 12 patients with knee OA as positive control group and 13 volunteers as healthy control group. All participants were given 4 weeks of quadriceps-hamstring isometric home-based training. At baseline and at the end of the program, WOMAC and Lequesne algofunctional index scores of knee OA patients and DAS28-CRP scores of RA patients were recorded. Dominant knee thickness and pennation angle measurements of QF muscle parts were evaluated by ultrasonography.
Investigators
Ovgu Bickici
OB
Hatay Dortyol State Hospital
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Change of quadriceps femoris parts thickness measures
Time Frame: At baseline and after 4 weeks of intervention
Dominant knee vastus lateralis, medialis, intermedius and rectus femoris thicknesses of 3 groups were calculated at baseline and at the end of intervention.
Change of quadriceps femoris parts pennation angles
Time Frame: At baseline and after 4 weeks of intervention
Pennation angles of vastus lateralis, medialis and intermedius were calculated at baseline and at the end of exercise program.
Secondary Outcomes
- Change of The Western Ontario and McMaster Universities Arthritis Index (WOMAC) score of knee OA(At baseline and after 4 weeks of intervention)
- Change of Disease activity score 28-C reactive protein (DAS28-CRP)(At baseline and after 4 weeks of intervention)
- Change of Lequesne scores of knee OA patients(At baseline and after 4 weeks of intervention)