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Clinical Trials/NCT07386535
NCT07386535
Recruiting
Not Applicable

Innovative Tools to Expand Music-Inspired Strategies for Blood Pressure and Stroke Prevention

Washington University School of Medicine1 site in 1 country1,412 target enrollmentStarted: February 1, 2026Last updated:

Overview

Phase
Not Applicable
Status
Recruiting
Enrollment
1,412
Locations
1
Primary Endpoint
Proportion of youth participants with blood pressure <120/80 mmHg

Overview

Brief Summary

Expanding evidence-based interventions for hypertension and stroke prevention among youth and their caregivers is crucial for meeting World Health Organization and Nigerian health goals. Innovative strategies are urgently needed to address the burden of hypertension and stroke in Nigeria, aiming to involve local communities, bridge generational gaps, and reduce health disparities. This study aims to determine the effect of a music-inspired intervention and campaign (Music4Health) designed by the community on blood pressure, stroke preparedness and intentions, and uptake of the intervention among youth-caregiver dyads in Nigeria.

Detailed Description

This study will be a stepped-wedge cluster randomized controlled trial conducted in 30 local government areas in Nigeria. The aim of the study will be to test if the music-inspired intervention reduces blood pressure in caregivers ≥40 years old, maintains blood pressure in youth 14-24 years old, and improves stroke preparedness among youth and caregivers. Sites will be randomly assigned to one of four waves, which will deliver the intervention to a longitudinal cohort of youth-caregiver dyads, spaced one month between each wave. The control period will last three months and include no intervention, and the intervention period will last three months for each wave and will include three music listening sessions (Music4Health Day) spaced one month apart. Participants will be recruited and enrolled in the trial through various methods, including community outreach, referrals, and social media. Participants will be invited to attend three community-based Music4Health Days on predetermined dates (schedule based on randomized intervention waves) and will be asked to return to the intervention site for follow-up data collection, including blood pressure measurements and validated questionnaires. The Music4Health Day intervention will include a listening session of a music video with lyrics designed to improve knowledge and awareness of high blood pressure and stroke preparedness. During Music4Health Day, music ambassadors will also share personal experiences to promote health messages and foster community engagement. Following the intervention period, the investigators will follow the cohort for six months after the intervention period to collect outcome data from each participant.

Study Design

Study Type
Interventional
Allocation
Na
Intervention Model
Sequential
Primary Purpose
Prevention
Masking
None

Masking Description

None (Open Label)

Eligibility Criteria

Ages
14 Years to — (Child, Adult, Older Adult)
Sex
All
Accepts Healthy Volunteers
Yes

Inclusion Criteria

  • Youth Participants
  • Aged 14-24 years
  • Reside in one of the 30 selected LGAs
  • Able to provide informed consent
  • Willing to participate in the M4H campaign
  • Caregiver Participants
  • Aged ≥40 years
  • Identified as a caregiver (biological/surrogate parent, grandparent, or close relative)
  • Reside in the same household or have a caregiving relationship with eligible youth
  • Able to provide informed consent

Exclusion Criteria

  • Youth Participants
  • Below 14 or above 24 years
  • Inability to provide informed consent
  • Unwilling to participate in intervention activities
  • Caregiver Participants
  • Below 40 years of age
  • Not serving in a caregiver role to eligible youth
  • Inability to provide informed consent
  • General Eligibility for Dyads
  • Either party of the dyad does not meet the inclusion criteria

Arms & Interventions

Music4Health Intervention

Experimental

Each of the 30 local government areas (LGAs) will be randomly allocated using block randomization to one of the four waves, with 7-8 LGAs allocated to each wave. All waves will begin with a control period with the first wave commencing the intervention period three months following the study start and each subsequent wave commencing one month following the start date of the previous wave's intervention period. Each wave's intervention period will last three months.

Intervention: Music4Health Intervention (Behavioral)

Outcomes

Primary Outcomes

Proportion of youth participants with blood pressure <120/80 mmHg

Time Frame: Months 0, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, and 14

Systolic and diastolic blood pressure among youth participants will be measured three times at each time point using a digital sphygmomanometer by trained community health extension workers. The mean systolic and diastolic blood pressure from the three measures will be calculated for each time point. We will calculate the proportion of youth participants with a mean systolic and diastolic blood pressure \<120/80 mmHg for each time point.

Mean change in systolic blood pressure among caregiver participants

Time Frame: Months 0, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, and 14

Systolic blood pressure among caregiver participants will be measured three times at each time point using a digital sphygmomanometer by trained community health extension workers. The mean systolic blood pressure from the three measures will be calculated for each time point. Change in systolic blood pressure will be calculated as the difference in systolic blood pressure from baseline (month 0) to each endpoint.

Percent accuracy on a stroke knowledge and preparedness assessment

Time Frame: Months 0, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, and 14

Stroke knowledge and preparedness will be assessed using a self-administered 13-item multiple-choice tool assessing knowledge of stroke symptoms, appropriate responses to stroke symptoms, and the ability to accurately identify a stroke in case examples. This knowledge assessment tool is a modified version of a tool used in the HipHop Stroke Study.

Uptake of music-inspired hypertension/stroke prevention campaign (Music4Health) among youth and caregiver participants

Time Frame: Months 0, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, and 14

Uptake of the campaign is defined as the absolute number, proportion, and representativeness of participants who participate in the campaign (i.e., attend listening sessions).

Secondary Outcomes

  • Intervention Acceptability(Months 0, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, and 14)
  • Intervention Fidelity(Months 0, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, and 14)
  • Intervention Reach(Months 0, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, and 14)
  • Intervention Sustainment(Months 0, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, and 14)

Investigators

Sponsor Class
Other
Responsible Party
Sponsor

Study Sites (1)

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