Does Automated closed-loop ventilation Reduce the DRiving Pressure levels in patients with ARDS (AiRDRoP) - an international multi-center crossover study and randomized controlled trial

Completed

• Conditions: acute lung injury; ARDS; 10024967

• Registration Number: NL-OMON46892
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 30

Inclusion Criteria

- Moderate/severe ARDS
- Intubated and ventilated
- Within 24 hours of initial diagnosis of ARDS

Exclusion Criteria

- Age <18
- Previously included in this study or other interventional trial that could influence ventilation parameters
- Suspected or confirmed pregnany
- Increased or uncontrollable intracranial pressure
- Contra-indication for esophageal pressure measurement

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Transpulmonary driving pressure</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- End expiratory pressure in the respiratory system<br /><br>- End expiratory pressure in the esophagus<br /><br>- End inspiratory pressure in the respiratory system<br /><br>- End inspiratory pressure in the esophagus<br /><br>- tidal volume (Vt)<br /><br>- positive end-expiratory pressure (PEEP)<br /><br>- plateau pressure (Pplat)<br /><br>- peak pressure (Ppeak)<br /><br>- respiratory rate (RR)<br /><br>- fraction of inspired oxygen (FiO2)<br /><br>- exhaled CO2 (etCO2 en VCO2)<br /><br>- peripheral oxygen saturation (spO2)<br /><br>- CO2 tension in arterial blood (PaCO2)<br /><br>- oxygen tension in arterial blood (PaO2)<br /><br>- oxygen saturation in arterial blood (saO2)<br /><br>- pH of arterial blood<br /><br>- bicarbonate in arterial blood (HCO3)</p><br>