The Effect of Household Air Pollution on Lung Function Growth in Infants With Pneumonia in Sub-Saharan Africa
试验速览
- 阶段
- 不适用
- 状态
- Enrolling By Invitation
- 入组人数
- 25
- 试验地点
- 1
- 主要终点
- Feasibility and acceptability of the clean intervention
研究概览
简要总结
This study will evaluate the feasibility and acceptability of a household-based clean air intervention
详细描述
A clean air intervention will be implemented in each household, including HEPA- based air filtration, solar lighting, and education. The air filtration system will be cycled monthly, with active filtration alternating with no filtration for one month on/one month off. To determine the effect of the clean air intervention within the household, PM2.5 concentration during each cycle and lung function will be measured among household members.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Sequential
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 1 Month 至 11 Months（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age < 12 months
- •First episode of WHO-defined severe pneumonia22: cough or difficulty breathing with
- •Oxygen saturation < 90% or central cyanosis,
- •Severe respiratory distress, or
- •Signs of pneumonia with a general danger sign
- •Be willing to commit to entire 2 years of follow up visits.
- •(Controls) Matched to each case on age (+/-1 month), sex, and community
排除标准
- •Craniofacial, cardiac or other major malformation
- •Neuromuscular condition that affects respiration
- •Outside Smart Discharges Project catchment area
- •Prior hospitalizations or known episodes of respiratory illness or episodes of pneumonia before index admission,
结局指标
主要结局
Feasibility and acceptability of the clean intervention
时间窗: 2 years
Adherence with the intervention (% total up-time of the air purifier)
次要结局
- Acceptability of using air filter device(Up to 2 years)
- Pulmonary function testing(Up to 2 years)
- Air quality(Up to 2 years)
研究者
Peter Moschovis
Principal Investigator, Pediatric Pulmonologist
Massachusetts General Hospital