Understanding Motivation in Parkinson's Patients Through Neurophysiology

Not Applicable

Active, not recruiting

• Conditions: Motivation; Parkinson Disease; Deep Brain Stimulation
• Interventions: Other: Stimulation on; Other: Stimulation off; Behavioral: Decision Making Task

• Registration Number: NCT05065151
• Lead Sponsor: University of California, San Francisco

Brief Summary

The study's aim is to better understand motivation and value-based decision making in Parkinson's patients through neurophysiology using Medtronic's Percept PC DBS device.

Detailed Description

The investigators will ask patients to complete reward-based decision making tasks in clinic and at home in the presence and absence of Percept PC deep brain stimulation and medication. The Percept PC device has the ability to stream data during paradigms and chronically at home. Patients at home will also be fitted with a wearable device which records motion, sleep, heart rate variability, and self-reported metrics. The investigators will use spectral techniques and statistical analysis to identify the relationship between brain signals and motivation.

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study First Submitted: 2021-09-17
• Study First Submitted QC: 2021-09-29
• Study First Posted: 2021-10-01
• Study Start: 2021-10-30
• Status Verified: 2024-12
• Last Update Submitted: 2024-12-06
• Last Update Posted: 2024-12-09
• Primary Completion: 2025-10-01
• Study Completion: 2025-10-01

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• Has Parkinson's Disease
• Has Medtronic Percept PC DBS device implanted in either GPI or STN

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Exclusion Criteria

• Severe cognitive impairments

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Stimulation	Stimulation on	Patients will be getting standard clinically acceptable stimulation within already safety validated stimulation ranges through their Medtronic Percept PC device.
Stimulation	Decision Making Task	Patients will be getting standard clinically acceptable stimulation within already safety validated stimulation ranges through their Medtronic Percept PC device.
No Stimulation	Stimulation off	Patients will have stimulation turned off through their Medtronic Percept PC device.
No Stimulation	Decision Making Task	Patients will have stimulation turned off through their Medtronic Percept PC device.

Primary Outcome Measures

Name	Time	Method
Percent of Risky Decisions made with Percept PC DBS stimulation on for Parkinson's Disease Patients	The values will be collected starting from admission in clinic and the at-home paradigm. Data collection and analysis of said values can take up to three years	Patients' responses on the tablet will be recorded in-clinic and at home. The investigators will tally their choices from the value-based decision making game (risky versus safe decisions) and report an average of risky responses.
Percent of Risky Decisions made with Percept PC DBS stimulation off for Parkinson's Disease Patients	The values will be collected starting from admission in clinic and the at-home paradigm. Data collection and analysis of said values can take up to three years	Patients' responses on the tablet will be recorded in-clinic and at home. The investigators will tally their choices from the value-based decision making game (risky versus safe decisions) and report an average of risky responses.

Trial Locations

Locations (1)

University of California San Francisco; 🇺🇸 San Francisco, California, United States