The evaluation of oral vitamin D on improvement of patients with oral erosiver-atrophic lichen planus: Double blind randomized clinical trial

Mashhad University of Medical Sciences0 个研究点目标入组 28 人开始时间: 待定最近更新: 2018年3月26日

适应症

试验速览

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•1. Patients with erosive-atrophic oral lichen planus with confirmation of clinical diagnosis and histopathology confirmation. 2. Patients have not used any systemic or topical drug for the treatment of lichen planus over the past 2 weeks. 3. In the past 3 months, they have not used any vitamin supplements. 4. Patients aged 18-80 years old were considered. 5. People with vitamin D deficiency or insufficiency (25 (OH) D <30 mg / dl). 6. Patients with grade 2 to 5 Thongprosam criteria will enroll in this study.

•1. People who have been diagnosed with , mild to severe dysplasia. 2. Calcium levels above 10 mg / dl, phosphorus less than 2.5 mg / dl (rejection of hyperparathyroidism) 3. lichenoid reaction. 4. Patients who do not have the necessary co-operation or attending the control sessions. 5. Pregnant women 6. Metabolic bone diseases such as: osteomalacia and primary hyperparathyroidism (with endocrinologist confirmation) 7. Patient with a history of severe renal-hepatic dysfunction 8. Chronic inflammatory disease in addition to lichen planus 9. If you have a history of being allergic to vitamin D supplements (itching, inflammation or redness in the skin and cramps, then using the supplementation of this vitamin) 10. Patients who use barbiturates and phenytoin. 11. Patients with granulomatous diseases, including sarcoidosis 12. History of malabsorption or chronic pancreatitis

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