A comparative study of two drugs, magnesium sulphate and budesonide in reducing the incidence and severity of post operative sore throat.

Phase 4

Active, not recruiting

• Conditions: Medical and Surgical,

• Registration Number: CTRI/2021/03/032191
• Lead Sponsor: Laishram Rani Devi

Brief Summary

A double blinded, randomised control trial will be conducted in my Institution to compare the effectiveness of preoperative nebulisation of two drugs Magnesium sulphate and Budesonide in reducing the incidence and severity of Postoperative Sore Throat in patients undergoing elective surgery under general anaesthesia with endotracheal intubation.

Detailed Description

Not available

Study Timeline

• Study Start: 2021-03-24
• Last Update Posted: 2021-09-14

Recruitment & Eligibility

• Status: Closed to Recruitment of Participants
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

• Patients who have signed written informed consent.
• Patients with ASA grade I-II Patients undergoing Elective surgery under general anaesthesia with endotracheal intubation.
• Patients undergoing surgery in supine position.

Exclusion Criteria

• Patient refusal.
• History of known allergy to the drugs.
• History of cough or Upper Respiratory Tract illness.
• History of Respiratory diseases like COPD, Asthma etc.
• History of smoking Mallampati score >II More than one attempt of intubation.
• Patients undergoing oral or nasal surgeries.
• Patients on long term anti-inflammatory analgesic medications.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To compare the effectiveness of magnesium sulphate and budesonide in reducing the incidence and severity of post operative Sore throat	0hr, 2hrs, 24hrs and 48hrs after extubation

Secondary Outcome Measures

Name	Time	Method
To assess the hemodynamic profile of the nebulised drugs and their acceptability score	Before and After nebulisation, Intraoperatively

Trial Locations

Locations (1)

Jawaharlal Nehru Institute of Medical Sciences; 🇮🇳 East, MANIPUR, India

Jawaharlal Nehru Institute of Medical Sciences

🇮🇳East, MANIPUR, India

Laishram Rani Devi

Principal investigator

8617878542

ranilaishram95@gmail.com