Outpatient Lung Impedance-Guided Preventive Therapy in Patients With Chronic Heart Failure (CHF)
试验速览
- 阶段
- 3 期
- 入组人数
- 300
- 试验地点
- 2
- 主要终点
- Reduction of hospitalization for acute heart failure
研究概览
简要总结
Patients suffering from Chronic Heart Failure (CHF) are hospitalized for acute heart failure (AHF) several times a year. Currently, we have no method for prediction of future developments of AHF. In our center we have investigated the monitoring of lung impedence as a predictor for future deterioration. It was found that a decrease in lung impedence of more than 15% from normal value predicts AHF development with sensitivity of 98%. In this study we try to prove the hypothesis that preventive treatment according to lung impedence value may prevent future hospitalizations for AHF and improve clinical outcome.
Patients recruited by year:
2011 - 50; 2012 - 25; 2013 - 35; 2014 - 30; 2015 - 50; 2016 - 5
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients suffering from CHF, NYHA II-IV class
- •LV lower than 35% to LV lower than 45%
排除标准
- •Patients with additional disease with life-expectancy of less than 2 years
结局指标
主要结局
Reduction of hospitalization for acute heart failure
时间窗: Five years
次要结局
- Improved clinical outcome for CHF patients(Five years)