A comparative study on steroid therapy in children with nephrotic syndrome
- Conditions
- ephrotic syndrome
- Registration Number
- SLCTR/2016/027
- Lead Sponsor
- niversity Renal Clinic
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 64
1. Patients presenting with nephrotic syndrome between 1 yr to 12 yrs of age.
2. 1st episode of nephrotic syndrome, defined as patients with gross proteinuria (+++ or more) with UPcr > 200mg/mmol hypoalbuminemia (albumin>2.5g/dl) and odema.
3. Relapse of nephrotic syndrome, defined as gross proteinuria of +++ or more or UPcr >200mg/mmol for more than 3 days in a child who has been previously diagnosed of having nephrotic syndrome.
1. Patients who are resistance to prednisolone, defined as Faliure to achieve remission after 28 days of daily prednisolone given at a dose of 60mg/m2/day
2. Remission achieved after more than 28 days of daily prednisolone.
3. Nephroic syndrome secondary to systemic diseases
4. Patients having gross hematuria
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Duration of remission – Time Period from the initial remission to the 1st relapse.<br>2. Relapse rate – Number of relapses per year.<br>3. Duration to become Steroid dependent or Frequent Relapsing.<br> [Monthly until remission is reached, and then every 2 months for a period of three years]<br>
- Secondary Outcome Measures
Name Time Method Stunting<br>Obesity<br>Cataract [Height and weight will be measured every month while on treatment and every 3months while in remission and plotted in the centile charts<br>]<br>