The Clinical Epidemiology of Scrub Typhus in Humans, Chiggers and Rodents
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 1,200
- 主要终点
- Identify key mite vectors and rodent hosts involved in scrub typhus natural history, human infection, and disease virulence
研究概览
简要总结
This study to collect and identify rodents and mites across transects through diverse habitats used by the human community from a localised area identified as a scrub typhus 'hot spot'.
详细描述
Study design:
The project will undertake a detailed investigation of one human community, and its environment, at risk of scrub typhus:
Chiggers, Rodents & Habitat Study:
Transects across diverse habitats determining spatial distribution of species of chiggers and rodents. This will be performed 3x/year.
High-resolution habitat mapping. Comparison of genomes of O. tsutsugamushi detected in different environments, using attempted WGS.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 10 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Acute scrub typhus (Group 1)
- •Presenting with fever >38 C and testing positive by scrub typhus RDT.
- •Male or Female, aged 10 years or above.
- •Participant is willing and able to give informed consent for participation in the study.
- •Scrub typhus serosurvey (Group 2)
- •Villagers living in an environment in which scrub typhus is known to be present, who are asymptomatic.
- •Male or Female, aged 10 years or above.
- •Participant is willing and able to give informed consent for participation in the study.
排除标准
- •Acute scrub typhus (Group 1)
- •Villagers/patients under 10 years of age.
- •Those unwilling to give written informed consent.
- •Scrub typhus serosurvey (Group 2)
- •Villagers/patients under 10 years of age.
- •Those unwilling to give written informed consent.
结局指标
主要结局
Identify key mite vectors and rodent hosts involved in scrub typhus natural history, human infection, and disease virulence
时间窗: up to 24 months
determine the diversity of O. tsutsugamushi genotypes infecting rodents and mites and link these to their geographical distribution and associated habitat characteristics.
时间窗: up to 24 months
Correlate the frequency of O. tsutsugamushi in mites and rodents with habitat characteristics, to define interactions between distribution and transmission dynamics.
时间窗: up to 24 months
次要结局
- Identify human-derived O. tsutsugamushi genotypes to define genomic relationships between human, rodent and mite-derived genotypes.(up to 24 months)
- To interlink the distribution of O. tsutsugamushi positive mites, rodents and humans with habitat characteristics to propose interventions to reduce the risk of human disease.(up to 24 months)
- Identify putative determinants of human infection/virulence(up to 24 months)
- Determine changes in scrub typhus antibody titres over time and identify acutely infected scrub typhus cases(up to 24 months)