Combination Chemotherapy and Rituximab in Treating Patients With Chronic Lymphocytic Leukemia (CLL) That Did Not Respond to Fludarabine, CLL With Autoimmune Haemolytic Anemia (AIHA) or Richter's Transformation (RT)
- Conditions
- Chronic Lymphocytic Leukemia
- Registration Number
- NCT00309881
- Lead Sponsor
- German CLL Study Group
- Brief Summary
RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Monoclonal antibodies, such as rituximab, can block cancer growth in different ways. Some block the ability of cancer cells to grow and spread. Others find cancer cells and help kill them or carry cancer-killing substances to them. Giving more than one drug (combination chemotherapy) together with rituximab may kill more cancer cells.
PURPOSE: This phase II trial is studying how well giving combination chemotherapy together with rituximab works in treating patients with chronic lymphocytic leukemia (CLL) that has not responded to fludarabine (closed to entry as of 10/2006), CLL with autoimmune hemolytic anemia, or Richter transformation.
- Detailed Description
OBJECTIVES:
Primary
* Determine the efficacy, in terms of the rate and quality of remission, of chemotherapy comprising cyclophosphamide, doxorubicin hydrochloride, vincristine, prednisone, and rituximab (CHOP-R) in patients with fludarabine-refractory chronic lymphocytic leukemia (CLL) (closed to accrual as of 10/2006), CLL with autoimmune hemolytic anemia, or Richter transformation.
* Determine the incidence of infection in patients on CHOP-R regimen.
Secondary
* Determine the toxicity of this regimen in these patients
* Determine the progression-free and overall survival of patients treated with this regimen.
OUTLINE: This is a prospective, multicenter study. Patients are stratified according to disease (chronic lymphocytic leukemia (CLL) (closed to accrual as of 10/2006) vs CLL with autoimmune hemolytic anemia vs Richter transformation).
Patients receive cyclophosphamide IV, doxorubicin hydrochloride IV, and vincristine IV on day 1 and oral prednisone on days 1-5. Patients also receive rituximab IV on day 1 of the second course and each subsequent course. Treatment repeats every 21 days for up to 6 (for patients with CLL) or 8 (for patients with Richter's transformation) courses in the absence of disease progression or unacceptable toxicity.
PROJECTED ACCRUAL: A total of 75 patients will be accrued for this study.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 75
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Rate of remission Quality of remission
- Secondary Outcome Measures
Name Time Method Toxicity Progression-free survival Overall survival
Trial Locations
- Locations (18)
Kreiskrankenhaus
🇩🇪Bad Hersfeld, Germany
Internistische Onkologische Praxis - Kronach
🇩🇪Kronach, Germany
Universitaetsklinikum Essen
🇩🇪Essen, Germany
Klinikum der Universitaet Muenchen - Grosshadern Campus
🇩🇪Munich, Germany
Clinic for Bone Marrow Transplantation and Hematology and Oncology
🇩🇪Idar-Oberstein, Germany
DIAKO Ev. Diakonie Krankenhaus gGmbH
🇩🇪Bremen, Germany
Internistische Gemeinschaftspraxis - Kassel
🇩🇪Kassel, Germany
Haematologische Praxis
🇩🇪Weiden, Germany
Medizinische Universitaetsklinik I at the University of Cologne
🇩🇪Cologne, Germany
Marienhospital at Ruhr University Bochum
🇩🇪Herne, Germany
St. Marien Hospital - Katholisches Krankenhaus Hagen gGmbH
🇩🇪Hagen, Germany
Allgemeines Krankenhaus Hagen
🇩🇪Hagen, Germany
Asklepios Klinik St. Georg
🇩🇪Hamburg, Germany
Praxis fur Innere Medizin - Hamburg
🇩🇪Hamburg, Germany
Klinikum Oldenburg
🇩🇪Oldenburg, Germany
Gemeinschaftspraxis Fuer Innere Medizin, Hematologie Und Onkologie
🇩🇪Giessen, Germany
Marienhospital Stuttgart
🇩🇪Stuttgart, Germany
Medizinische Poliklinik, Universitaet Wuerzburg
🇩🇪Wuerzburg, Germany