Measuring the Impact of Real Time fMRI Neurofeedback in Borderline Personality Disorder
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Borderline Personality Disorder
- Sponsor
- Yale University
- Enrollment
- 3
- Locations
- 1
- Primary Endpoint
- Change in Affective Lability
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
This study will test the impacts of real time fMRI neurofeedback in patients with Borderline Personality Disorder. This is a pilot study in a small number of people enrolled in clinical programs at Yale New Haven Hospital.
Investigators
Eligibility Criteria
Inclusion Criteria
- •enrolled in YNHH DBT-IOP
- •must meet specific clinical criteria
- •Inclusion in Experimental group requires participants meet standard safety and quality control requirements for MR scanning
- •For female participants, not pregnant and willing to use a reliable method of contraception during the study
Exclusion Criteria
- •vision problem not able to be corrected to normal range
- •medication changes w/in one month
- •Lifetime hx of schizophrenia, schizoaffective d/o, bipolar I disorder.
- •illicit substance use within 7 days of MRI scans
- •taking scheduled opiates
- •taking scheduled benzodiazepines
- •taking scheduled anti-histamines
- •history of seizures
- •significant current or past neurologic illness
- •BMI \< 16.5
Outcomes
Primary Outcomes
Change in Affective Lability
Time Frame: Baseline compared to the week after intervention
This outcome will be measured by the change in variance of negative emotions measured using ecologic momentary assessment (EMA: surveys sent to participants by smartphone app) repeatedly over a four-day period at each timepoint. The variance between measurements at each timepoint will be calculated, and compared to the other timepoints. There will be 5 negative emotion items at each timepoint, and a higher score indicates more negative emotion.
Secondary Outcomes
- Change in Mean Negative Affect(Baseline compared to the week after intervention)
- Change in Amygdala Regulation(Baseline compared to the week after intervention)
- Change in Borderline Personality Disorder Symptoms(Baseline compared to the week after intervention)