Confocal Laser Micro-endoscopy: New Insights in COPD and Lung Transplant Recipients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- KU Leuven
- 入组人数
- 176
- 试验地点
- 1
- 主要终点
- morphometry
研究概览
简要总结
Aspects of confocal laser micro-endoscopy (CLME) and morphometry in chronic obstructive pulmonary disease (COPD) and lung transplant recipients is described and will be correlated with clinical findings in order to described small airway remodelling in these patients.
详细描述
In early phases of COPD, changes in small airway characteristics may develop. Elastin decay and matrix remodelling could be responsible for these changes. Using CLME changes of in the bronchiolar wall and alveolar ducts can be visualized, described and measured.
In lung transplant recipients, CMLE will be performed to distinguish characteristics of distal airways in stabile patient in contrast to patients with bronchiolitis obliterans syndrome.
In both groups data will be correlated with CT findings, pulmonary function tests and anatomopathological results.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •referral for bronchoscopic investigation/sampling
- •informed consent signed
- •recent spirometric data
排除标准
- •sedated and/or ventilated patients
- •patients on ICU
- •patients under oral anticoagulation
- •co-existing lung disease
- •acute infectious pulmonary disease
结局指标
主要结局
morphometry
时间窗: 90 - 180 - 360 - 540 - 720 days
morpohometrical analysis at different time point after lung transplantation
次要结局
- adverse events(90 - 180 - 360- 540- 720 days)