Evaluation of the effect of continuous positive airway pressure treatment on cardiopulmonary exercise capacity in Chinese patients with moderate to severe obstructive sleep apnea
- Conditions
- obstructive sleep apneaRespiratory - Sleep apnoea
- Registration Number
- ACTRN12622000467730
- Lead Sponsor
- Cheng Hei Shun
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 60
a) Chinese patients
b) 18 – 70 years old
c) Newly diagnosed with moderate to severe OSA confirmed by polysomnography (PSG)
a) Pre-existing known pulmonary/cardiac diseases
b) Left ventricular ejection fraction (LVEF) <50% or significant valvular disease detected in echocardiogram
c) Ethnicity other than Chinese
d) Invalid informed consent
e) Previously or currently on OSA treatment (CPAP/Oral appliance/Surgical treatment)
f) Sleep disorder other than OSA (e.g. central sleep apnea)
g) Obesity hypoventilation syndrome
h) Contraindication to CPAP treatment
i) Contraindication to cardiopulmonary exercise test
j) Known thyroid/renal/hepatic/neurological disease
k) Known musculoskeletal disorder
l) Mentally incapable
m) Anaemia
n) Peripheral vascular disease
o) Alcohol/substance abuse
p) Current medication including sedatives/sympathomimetics
q) Acute respiratory/cardiovascular event within six weeks of cardiopulmonary exercise test
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method