Study of Arithmetic Abilities of Children With 22q11.2 Deletion Syndrome Aged From 4 to 11 Years Old
Trial Snapshot
- Phase
- Not Applicable
- Status
- Terminated
- Sponsor
- Enrollment
- 41
- Locations
- 2
- Primary Endpoint
- Percentage of impaired scaled score
Study Overview
Brief Summary
The study ARITH22 will investigate the role of visuo-spatial attention on arithmetic abilities of children with 22q11.2 deletion syndrome.
Detailed Description
Children with 22q11.2 deletion syndrome often have arithmetic learning disability because of magnitude representation impairment. Previous works suggested that magnitude representation impairment could be a result of endogenous visuo-spatial attention dysfunction in 22q11.2DS. Nevertheless this relationship is still poor explored. The influence of visuo-spatial abilities on arithmetic achievement could also be modulated by developmental age. The study ARITH22 will test these hypotheses thanks to magnitude comparisons tasks, in children with 22q11.2 deletion syndrome and matched children without developmental disease.
Study Design
- Study Type
- Interventional
- Allocation
- Non Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Basic Science
- Masking
- None
Eligibility Criteria
- Ages
- 4 Years to 11 Years (Child)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Diagnosis of 22q11.2 deletion syndrome or no developmental disease
- •Aged from 4 to 11 years old
- •French language
Exclusion Criteria
- •Diagnosis of intellectual deficiency according to DSM 5 criteria
- •Drug prescribed for somatic condition that could influence cerebral functioning
Outcomes
Primary Outcomes
Percentage of impaired scaled score
Time Frame: single day
percentage of impaired scaled score at ZAREKI-R
Secondary Outcomes
- Percentage of correct responses(single day)
- Mean reaction time(single day)