Optimal cerebral perfusion after an extracranial-intracranial bypass: should we increase blood pressure or cardiac output?
Completed
- Conditions
- Cerebrovascular diseasevascular disease in the brain10007963
- Registration Number
- NL-OMON46670
- Lead Sponsor
- Anesthesiologie
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 10
Inclusion Criteria
Adults, aged 18 years or above
Indication for extracranial-intracranial bypass surgery
Exclusion Criteria
Patients within two weeks after a subarachnoid hemorrhage
Language barrier
Pregnancy
Hypertrophic cardiomyoapthy
Left ventricular outflow tract obstruction
Severe, untreated, ventricular arrhythmia
Severe hyperthyroidism
Recent myocardial infarction (<30 days) or unstable angina
Hypersensitivity to dobutamine or phenylephrine
Mean arterial blood pressure < 60 mmHg under general anesthesia before start of the study period
Systolic blood pressure > 180 mmHg under general anesthesia before start of the study period
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The mean change in graft flow rate (ml/min) during dobutamine administration to<br /><br>increase the cardiac output with 10% and the mean change in flow rate during<br /><br>administration of phenylephrine to increase the blood pressure with 10%. </p><br>
- Secondary Outcome Measures
Name Time Method <p>Secondary endpoints are the difference in change in graft flow rate, cardiac<br /><br>output and blood pressure (compared to the reference stage) between the<br /><br>intervention to increase the cardiac output and the intervention to increase<br /><br>the blood pressure. </p><br>