Graft-versus-host Disease Associated Myelosuppression

• Conditions: Abnormal Hematopoiesis; Graft vs Host Disease; Allogenic Disease

• Registration Number: NCT02829216
• Lead Sponsor: Technische Universität Dresden

Brief Summary

The objective is to measure the frequency, functionality and phenotype of bone marrow-derived mesenchymal stromal cells in patients after allogeneic hematopoietic stem cell transplantation. Furthermore, the immune cell infiltrate of the bone marrow will be monitored at the same time. These results will be correlated with the extent of cytopenia and clinical graft-versus-host disease grading.

Detailed Description

Not available

Study Timeline

• Study Start: 2016-04
• Study First Submitted: 2016-05-17
• Status Verified: 2016-07
• Study First Submitted QC: 2016-07-07
• Last Update Submitted: 2016-07-07
• Study First Posted: 2016-07-12
• Last Update Posted: 2016-07-12
• Primary Completion: 2017-04

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• age >18
• acute myeloid leukemia
• myelodysplastic syndrome
• hematopoietic stem cell transplantation

Exclusion Criteria

• not willing to take part

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Changes in the amount of mesenchymal stromal cells after allogeneic hematopoietic stem cell transplantation	up to 1 year after allogeneic hematopoietic stem cell transplantation

Trial Locations

Locations (1)

Medizinische Klinik und Poliklinik I, Universitätsklinikum, TU Dresden; 🇩🇪 Dresden, Germany