Evaluation of diurnal variation in forced vital capacity in patients with fibrotic interstitial lung diseases using home spirometry

Completed

• Conditions: fibrotic interstitial lung diseases; pulmonary fibrosis; 10024967

• Registration Number: NL-OMON46263
• Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 11 June 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 50

Inclusion Criteria

Patients diagnosed with fibrotic interstitial lung disease

Exclusion Criteria

- Not able to speak, read or write in Dutch
- Not able to comply to the study protocol, according to the judgement of the investigator and/or patient
- Life expectancy less than six months, according to the judgment of the investigator.

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary outcome is the difference in FVC between measurements in the<br /><br>morning and afternoon</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- Difference in Forced Expiratory Volume in 1 second (FEV1) between<br /><br>measurements in the morning and afternoon.<br /><br><br /><br>- Difference in Peak Expiratory Flow (PEF) between measurements in the morning<br /><br>and afternoon.<br /><br><br /><br>- Difference in HRQOL at baseline and after 6 weeks measured by K-BILD.<br /><br><br /><br>- Exploratory comparison of the differences in change in FVC between<br /><br>different fibrotic interstitial lung diseases.<br /><br><br /><br>- Difference in activity (steps) between morning and afternoon</p><br>