Development and Validation of a Risk Score for Predicting Severe Outcomes Among Children Hospitalized With Community-acquired Pneumonia

Children's Hospital of Fudan University1 site in 1 country6,000 target enrollmentJanuary 1, 2017

ConditionsPneumonia Child Prognosis

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Pneumonia
Sponsor: Children's Hospital of Fudan University
Enrollment: 6000
Locations: 1
Primary Endpoint: in-hospital mortality
Status: Completed
Last Updated: 3 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

In this study, investigators aimed to develop and validate a risk score to predict severe outcomes (e.g., mortality and ICU admission) in children who were admitted to the Children's Hospital of Fudan University between 2017 and 2022 due to community-acquired pneumonia (CAP). The objectives were as follows.

Develop a risk prediction model based on demographic, comorbidity, clinical characteristics, laboratory data, and chest radiographic reports to predict severe outcomes among children hospitalized with CAP;
Develop a risk scoring system and determine the cut-off point;
Externally validate the easy-to-use risk score.

Registry

clinicaltrials.gov

Start Date

January 1, 2017

End Date

December 31, 2022

Last Updated

3 years ago

Study Type

Observational

Sex

All

Investigators

Sponsor

Children's Hospital of Fudan University

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•Aged between 29 days and 18 years old;
•Admitted to hospital with signs or symptoms of acute infection (eg, fever) and acute respiratory illness (eg, cough), and radiographic evidence of pneumonia.

Exclusion Criteria

•Pneumonia developed 48 hours after admission or intubation;
•Chronic pneumonia, tuberculosis, tracheobronchial foreign bodies, aspiration pneumonia, parasitic lung disease, and diffuse pulmonary interstitial/parenchyma disease.

Outcomes

Primary Outcomes

in-hospital mortality

Time Frame: from admission to discharge, an average of 7 days

in-hospital mortality among children hospitalized with CAP

Secondary Outcomes

admission to ICU(from admission to discharge, an average of 7 days)
septic shock(from admission to discharge, an average of 7 days)
treatment for severe pneumonia(from admission to discharge, an average of 7 days)