pattern of use of antihypertensive agents in elderly hypertensive patients with or without concomitant diseases.

Completed

Conditions: Elderly hypertensive patients aged more than 60 years with or without co morbid conditions

Registration Number: CTRI/2018/06/014662

Lead Sponsor: DR Champakala C

Brief Summary: 1) 1) Prescriptions of 250 elderly hypertensivesubjects with or without co morbidity were assessed for the pattern of antihypertensive agents use.

2)     The mean age of the study subjects was 67.9 Â± 4.05years and out of 250 subjects, 119subjects received anti hypertensive agents as mono therapy, includes antihypertensive agents such as CCB (47.8%), ARB (34.5%), beta blockers (13.4%),ACEI (3.4%) & alpha blockers (0.8%).

3)     The two most commonly prescribed antihypertensive agents in the study either as mono therapy or in combination withthe other anti hypertensive agents were ARB (55%) & CCB (55%).

4)     Dual anti hypertensive combination therapy wasprescribed to 100 subjects and the most common dual anti hypertensivecombination therapy was ARB + thiazide diuretic. Triple anti hypertensiveagents combination therapy was prescribed to 26 subjects, 3 subjects received4-anti hypertensive agents combination therapy and only 1 subject wasprescribed with 5-anti hypertensive agents combination therapy.

5)     42.8% of the study population receivedantihypertensive FDCs. There were 20 different FDCs of antihypertensive agentsprescribed in the study, Telmisartan + hydrochlorthiazide was the most commonlyprescribed FDC.

6)     The level of medication compliance was assessedby 8-item questionnaire as per MMAS-8. Compliance level was good in 41.2%subjects, moderate in 48.4% subjects & poor in 10.4% subjects. Compliancelevel in the present study was influenced by various factors such as age, gender,socioeconomic status, comorbidities, severity of hypertension, number ofmedications, and cost of medications.

7)     HRQoL in the study subjects was assessed by17-item questionnaire as per MINICHAL Scale. In our study it has shown thatHRQoL in the subjects was influenced by severity of hypertension in the study.

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: All

Target Recruitment: 250

Inclusion Criteria

Elderly patients of either gender aged 60 years and above with hypertension, with or without co morbid conditions, receiving anti hypertensive medications for more than 6 months.

Exclusion Criteria

Subjects with acute complications such as MI,Left Ventricular Failure,Cerebrovascular events, hypertensive emergencies or acute renal failure.
Subjects hospitalized for any other conditions.
Subjects with terminal illness due to malignancy.
Subjects with severe psychiatric illness or cognitive impairment.

Study & Design

Study Type: Observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To determine the pattern of anti hypertensive prescribing for elderly with or without coorbidities	18 months

Secondary Outcome Measures

Name	Time	Method
To assess the medication compliance and quality of life in the study subjects	18 months

Trial Locations

Locations (1): KIMS Hospital
🇮🇳
Bangalore, KARNATAKA, India
KIMS Hospital
🇮🇳Bangalore, KARNATAKA, India
DR Champakala C
Principal investigator
9008061029
champachannappa@gmail.com