Probing microglial activation in psychosis. - Probing microglial activation in psychosis.

niversitair Medisch Centrum Utrecht0 个研究点目标入组 50 人开始时间: 待定最近更新: 2024年5月6日

适应症

试验速览

暂无简介。

•-Men and women
•-Mini Mental State score >27
•-Written informed consent of the subject;Specific for patients with psychotic symptoms:
•- Presence of schizophrenic and psychotic symptoms according to DSM-IV criteria using the Comprehensive Assessment of Symptoms and History interview (CASH) (N.B. Official DSM-IV diagnosis can be performed six months after onset of symptoms.)

•Healthy controls:
•-History of psychiatric or neurological illness based (DSM-IV criteria)
•-First-degree relatives with a family history of schizophrenia or schizophrenia spectrum disorders
•-Any neurological disorder
•-(History of) Alcohol and/or drug abuse (DSM-IV criteria)
•-Any clinical significant abnormality of any clinical laboratory test, including drug screening (but positive cannabis test is allowed for patients)
•-Any condition that may interfere with MRI scanning, e.g. metal objects in or around the body or claustrophobia
•-Pregnancy;Specific for medicated patients with psychotic symptoms:
•- Any neurological disorder;Specific for first episode medication-naive patients with psychotic symptoms:
•- Use of antipsychotics
•- Treating physician does not support a delay of medication for the patient (from a clinical perspective)
•- Risk that the patient causes serious harm to oneself or others
•- Clinical Global Impressions Severity (CGI-S) score 5 or higher
•- Psychotic symptoms are too severe to participate (based on CGI-S score and clinical view of treating physician)

发起方

niversitair Medisch Centrum Utrecht