Transorbital and transtemporal ultrasound to predict EVD weaning failure in patients with increased intracranial pressure - a prospective, multicenter study
- Conditions
- G91.9Hydrocephalus, unspecified
- Registration Number
- DRKS00033089
- Lead Sponsor
- niversitätsmedizin Göttingen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- 190
Inclusion Criteria
Planned EVD weaning trial
Acute subarachnoid hemorrhage (SAH) or
Acute intracerebral hemorrhage with ventricular collapse or
Meningitis/encephalitis or
Acute cerebral edema or
Severe TBI (typically GCS 3-8)
Exclusion Criteria
Age < 18 years
Decompressive hemicraniectomy
Acute injuries to one and/or both eyes in which further damage cannot be reliably ruled out by the ONSD measurement (even with compliant device settings).
Z.n. Operations in the area of the orbit or N. II, which could influence the measurement result
Chronic inflammatory changes in the II nerve (e.g. multiple sclerosis)
Chronic ICP elevation (e.g. pseudotumor cerebri)
Chronic hydrocephalus syndromes
Chronic CSF hypotension syndromes
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method EVD-Weaning failure
- Secondary Outcome Measures
Name Time Method Optic nerve sheath diameter (ONSD) after 24 hours, change in ONSD from initial measurement and after 24 hours, CT/MR imaging: width of the 3rd ventricle; Evan’s index, parieto-occipital ratio (POR) and temporal ratio (TR)