Targeted Rehabilitation to Improve Outcome after total knee replacement

Not Applicable

Completed

• Conditions: Musculoskeletal Diseases; Gonarthrosis [arthrosis of knee]; Osteoarthritis of the knee

• Registration Number: ISRCTN23357609
• Lead Sponsor: niversity of Edinburgh/NHS Lothian (UK)

Brief Summary

2014 protocol in http://www.ncbi.nlm.nih.gov/pubmed/24484541 2018 results in https://doi.org/10.1093/rap/rky021 2020 results in https://pubmed.ncbi.nlm.nih.gov/33051212/ (added 22/10/2020)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2013-07-25
• Study Completion: 2017-07-15
• Last Update Posted: 2 November 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 1190

Inclusion Criteria

1. Undergoing primary total knee arthroplasty for osteoarthritis.
2. Patients are able to consent and willing to comply with the study protocol
3. TRIO-physio only: Defined poor outcome (Oxford Knee Score less than or equal to 26) at first post-op review (6
weeks).
4. TRIO-POPULAR only: Patients are eligible for inclusion if they are adults aged 16 years and over and understand oral and written English

Exclusion Criteria

1. Patients undergoing revision knee arthroplasty or fully constrained knee arthroplasty
2. Knee replacement for a diagnosis other than osteoarthritis
3. TRIO-Physio only: Patients unable to attend the study physiotherapy intervention centres.
4. TRIO-Physio only: Patients subjected to procedures done purely for pain relief (such as for patients with no walking capacity)

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Oxford Knee Score at 52 weeks

Secondary Outcome Measures

Name	Time	Method
<br> TRIO-Physio study only:<br> 1. Assess patient satisfaction with knee arthroplasty, pain relief and functional ability.<br> 2. Patient functional improvements following physiotherapy (Timed-get-up-and-go test)<br> 3. To evaluate the cost effectiveness of enhanced targeted physiotherapy.<br><br> TRIO-POPULAR study only:<br> Questionnaires to collect EQ5D, demographics, Hospital Anxiety and Depression Scale (HADS), social support, attitudes and concerns about illness, patient expectations about outcome, Pain Catastrophising Scale, Short-form Tampa Scale of Kinesophobia, Sleep Problem Scale, Prior health seeking behaviour, Pain Manikins, Co-morbidities, General Health (PROMIS), HPA, DNA collection, Brief Pain Inventory.<br>