Physiologic Mechanisms Underlying Ovarian Follicular Waves During the Menstrual Cycle
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Antral follicle diameter
研究概览
简要总结
The research aims to characterize changes in ovarian and pituitary hormones associated with the development of ovarian follicular waves during the human menstrual cycle.
详细描述
Our laboratory's previous research has demonstrated that multiple waves of ovarian follicles develop throughout the menstrual cycle. Approximately 2/3 of women develop 2 follicle waves throughout their cycle while the remainder exhibit 3 waves of follicle growth (1,2). This study is to follow up on those findings to determine how pituitary and ovarian hormones regulate the development of follicle waves in women, with a combination of ultrasound scans and blood and urine sampling to characterize how follicles grow during the menstrual cycle in 50 women of reproductive age. Changes in follicle growth across the cycle will be compared with changes in hormone production.
The new findings will be essential for improving understanding of female reproduction, with clinical applications in contraception, fertility and menopausal care for women across their reproductive lifespan.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Healthy biological females
- •Regular menstrual cycles (21-35 days)
排除标准
- •BMI <18 or >30
- •Pregnancy
- •Breastfeeding mothers
- •Current infertility
- •History of hysterectomy or oophorectomy
- •Reproductive health issues that can interfere with study outcomes
- •Metabolic syndrome (blood pressure, fasting glucose, fasting insulin and serum lipids measured to assess eligibility)
- •Not on any hormonal medication that affects reproduction (including hormonal contraception)
- •Hyperprolactinemia
- •Abnormal thyroid stimulating hormone assay
结局指标
主要结局
Antral follicle diameter
时间窗: One menstrual cycle (21-35 days) per volunteer
Daily diameters of individual follicles ≥ 2mm from ultrasound examination
Antral follicle count
时间窗: One menstrual cycle (21-35 days) per volunteer
Daily count of the number of follicles \>2 mm from ultrasound examination
Anti-mullerian hormone (AMH) serum level
时间窗: One menstrual cycle (21-35 days) per volunteer
Daily measurements of AMH in ng/mL
Inhibin B serum level
时间窗: One menstrual cycle (21-35 days) per volunteer
Daily measurements of inhibin B in pg/mL
Follicle stimulating hormone (FSH) serum level
时间窗: One menstrual cycle (21-35 days) per volunteer
Daily measurements of FSH in IU/L
Luteinizing hormone (LH) serum level
时间窗: One menstrual cycle (21-35 days) per volunteer
Daily measurements of LH in IU/L
Estradiol serum level
时间窗: One menstrual cycle (21-35 days) per volunteer
Daily measurements of estradiol in pg/mL
Progesterone serum level
时间窗: One menstrual cycle (21-35 days) per volunteer
Daily measurements of progesterone in ng/mL
Inhibin A serum level
时间窗: One menstrual cycle (21-35 days) per volunteer
Daily measurements of inhibin A in pg/mL
次要结局
未报告次要终点
研究者
Angela Baerwald
Associate Professor
University of Saskatchewan