Autonomic Nervous System (ANS) Analysis According to Different Renal Function Stage in Immunoglobin A (IgA) Nephropathy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 12
- 试验地点
- 1
- 主要终点
- Standard deviation of all R-R intervals (SDNN)
研究概览
简要总结
The estimation of the cardiovascular risk in the general population must take into account small renal disturbances, as the microalbuminuria. Conversely certain parameters of the cardiovascular risk influence the evolution of renal diseases, for example the arterial high blood pressure.
The measure of the activity of the autonomous nervous system, and especially the quantification of its variability, is a means to estimate the cardiovascular risk. The investigators formulate the hypothesis that the variability of the autonomous nervous system is an additional clinical element for the evaluation of the evolutionary risk of renal diseases.
The aim of this study is to compare the variability of the autonomous nervous system during the various evolutionary stages of the renal disease.
The renal disease studied will be IgA nephropathy (IgNA). IgNA is a histologically defined glomerulonephritis (rela biopsy) by the presence of deposits immunoglobulin A (IgA) in the renal mesangium (at list 1+) by immunofluorescence.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •diagnosis of IgNA biopsy-proven free, informed, express and written
排除标准
- •IgNA secondary to Henoch-Schonlein purpura (HSP) or Systemic Lupus Erythematosus or alcoholic cirrhosis
- •current kidney transplantation
- •Hypertension treated or not,
- •Diseases interfering with ANS analysis: cardiac arrhythmia, beta-blocker therapy
研究组 & 干预措施
IgAN with glomerular filtration rate (GFR) >90 ml/min/1.73 m2
Measure of ANS by holter device in IgAN patients with glomerular filtration rate (GFR) >90 ml/min/1.73 m2
干预措施: Holter (Device)
IgAN with GFR 60-89 ml/min/1.73 m2
Measure of ANS by holter device in IgAN patients with GFR 60-89 ml/min/1.73 m2
干预措施: Holter (Device)
IgAN with GFR 30-59 ml/min/1.73 m2
Measure of ANS by holter device in IgAN patients with GFR 30-59 ml/min/1.73 m2
干预措施: Holter (Device)
IgAN with GFR 15-29 ml/min/1.73 m2
Measure of ANS by holter device in IgAN patients with GFR 15-29 ml/min/1.73 m2
干预措施: Holter (Device)
IgAN with GFR < 15ml/min/1.73 m2
Measure of ANS by holter device in IgAN patients with GFR < 15ml/min/1.73 m2.
干预措施: Holter (Device)
结局指标
主要结局
Standard deviation of all R-R intervals (SDNN)
时间窗: day 1
Comparison of Standard deviation of all R-R intervals (SDNN) between GFR category of IgNA
次要结局
未报告次要终点