Acute Intermittent Hypoxia in Persons With Multiple Sclerosis
Not Applicable
Completed
- Conditions
- Multiple Sclerosis, Relapsing-Remitting
- Registration Number
- NCT04280484
- Lead Sponsor
- Shirley Ryan AbilityLab
- Brief Summary
The overall objective of this project is to investigate the effectiveness of Acute Intermittent Hypoxia (AIH), to improve muscle strength and activity level in individuals with relapsing-remitting MS.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 10
Inclusion Criteria
- Have relapsing-remitting MS
- Volitional ankle plantar flexion strength in at least one leg
- Are relapse free for 30 days
- Patient-Determined Disease Steps scale score between 3 and 5 (3=gait disability to 5=late cane, need cane to walk 25 feet)
Exclusion Criteria
- Currently taking antispasticity medications,
- Have cardiovascular or respiratory/pulmonary disorders, metabolic dysfunction, or prior diagnoses of obstructive sleep apnea
- Pregnant or nursing women (safety for developing fetus or infant is unknown)
- Cognitive concerns (must be able to consent to study, follow steps)
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Primary Outcome Measures
Name Time Method Voluntary Ankle Strength 60 minutes post-intervention Maximum isometric ankle plantar-flexion and dorsi-flexion torque using a Biodex
- Secondary Outcome Measures
Name Time Method Symbol Digit Modalities Test 60 minutes post-intervention The symbol-digit modalities test (SDMT) is a symbol substitution neuropsychological test that examines a person's attention and speed of processing
Electromyogram activity 60 minutes post-intervention Plantar-flexor and Dorsi-flexor electromyogram activity
Trial Locations
- Locations (1)
Shirley Ryan AbilityLab
🇺🇸Chicago, Illinois, United States
Shirley Ryan AbilityLab🇺🇸Chicago, Illinois, United States