Clinical Comparative Analysis of Bretschneider and St. Thomas Cardioplegia Solution in Case of Mitral Valve Repair Via Anterolateral Right Thoracotomy
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Mitral Valve Reconstruction
- Sponsor
- University Hospital, Basel, Switzerland
- Enrollment
- 200
- Locations
- 1
- Primary Endpoint
- Creatin-Phosphokinase (CK) (U/l)
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
Mitral valve reconstruction via minimal invasive antero- lateral thoracotomy is done in cardioplegia with a cardioplegic solution, either HTK-Bretschneider (Custidiol®) (a crystalloid intracellular solution) or St. Thomas (a crystalloid extracellular solution).
This study investigates HTK-Bretschneider versus St. Thomas cardioplegic solution regarding peri- and postoperative outcome, especially for cardiac biomarkers.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Mitral valve reconstruction via minimal invasive antero- lateral thoracotomy done in cardioplegia with a cardioplegic solution, either HTK-Bretschneider (Custidiol®) (a crystalloid intracellular solution) or St. Thomas (a crystalloid extracellular solution).
Exclusion Criteria
- •Mitral valve reconstruction via minimal invasive antero- lateral thoracotomy done in cardioplegia with cardioplegic Solutions other than HTK-Bretschneider (Custidiol®) (a crystalloid intracellular solution) or St. Thomas (a crystalloid extracellular solution).
Outcomes
Primary Outcomes
Creatin-Phosphokinase (CK) (U/l)
Time Frame: perioperative during minimal invasive surgery
cardial biomarker for myocardial damage
high specific troponin T (hs-TrT) (μg/l)
Time Frame: perioperative during minimal invasive surgery
cardial biomarker for myocardial damage
Creatinkinase Muscle- Brain (CK-MB) (U/l)
Time Frame: perioperative during minimal invasive surgery
cardial biomarker for myocardial damage
Secondary Outcomes
- mortality rate(from minimal invasive surgery until 30 days post surgery)
- length of stay in intensive care unit (days)(from minimal invasive surgery until 30 days post surgery)