A Case Series Investigating change in self-rated pain following Rotation to Methadone in Palliative Patients with Cancer Related Pain

Brisbane South Palliative Care Collaborative0 个研究点目标入组 20 人开始时间: 2009年12月14日最近更新: 2020年1月13日

适应症

试验速览

暂无简介。

•*Patients reporting uncontrolled pain (defined as 4 or greater on a numerical rating scale 0-10 despite the use of regular background narcotics +/- adjuvants
•*A component of the patients pain must be neoropathic as assessed using a validated neuropathic pain diagnostic assessment tool, the Douleur Neuropathique en 4 (DN4)
•*Able to give informed consent in English
•*Willing to be admitted to an inpatient facility for rotation to methadone
•*Mini mental state exam (MMSE) score = or above 25/30
•*Unsuitable for, or refusing, non-pharmacological interventions e.g. nerve blocks for pain

•*Patients less than 18 years of age
•*Patients in whom the use of methadone is contraindicated e.g. using Monoamine oxidase inhibitors (MAOs), active alcoholism
•*Patients with known risk factors for a prolonged QT interval
•*Patients who have received treatments in the past 2 weeks likely to impact on pain levels e.g. chemotherapy, or who receive such therapy during the study period
•*Changes in concomitant analgesic medication during the study period
•*Any patient, in the opinion of the researchers, who is unable to comply with the study protocol
•*Life expectancy less than 3 weeks

发起方

Brisbane South Palliative Care Collaborative