Identifying Saliva Markers of Patients With Stomach, Colorectal (Including Pre-cancer Polyp) and Pancreatic Cancers

• Conditions: Gastric Cancer; Colorectal Cancer and Pre-cancer Polyps; Pancreatic Cancer
• Interventions: Other: Salivary samples

• Registration Number: NCT01675258
• Lead Sponsor: Hadassah Medical Organization

Brief Summary

Colorectal cancers account for 783,000 new cases and cause 437,000 deaths per year across the world. Diagnosis in the early stages improves survival rates. Up to now, these cancers are mostly diagnosed only at later stages of the disease's course through histoimmune staining and molecular biology processes on the tissues biopsied from the gastrointestinal system under invasive diagnostic procedures of colonoscopy.

Oral fluid presents a large protein complexity and has been recently used as a diagnostic biofluid for oral, as well as systematic diseases. Using oral fluid as a bio-marker for the colorectal cancer can be advantageous as it contains gastrointestinal fluids, in addition to bacteria and bacteria lysate, which can also serve as a bio-markers' source for colorectal cancers. Proteomic technologies provide the tools needed to discover and identify disease-associated biomarkers.

The aim of the present study is to identify salivary bio-markers in patients suffering from colorectal cancers.

Detailed Description

Not available

Study Timeline

• Status Verified: 2012-07
• Study First Submitted: 2012-08-27
• Study First Submitted QC: 2012-08-27
• Last Update Submitted: 2012-08-27
• Study First Posted: 2012-08-29
• Last Update Posted: 2012-08-29
• Study Start: 2012-09
• Primary Completion: 2013-09

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 150

Inclusion Criteria

• Has not yet started treatment for the identified cancer

Exclusion Criteria

• medically compromised patients
• congenital syndromes
• being treated with radiotherapy or chemotherapy.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Control	Salivary samples	Healthy adults above the age of 18 years
Study	Salivary samples	Adult patients above the age of 18 years with gastric, colorectal (including pre-cancer polyps) or pancreatic cancer

Trial Locations

Locations (1)

Hadassah Medical Organization; 🇮🇱 Jerusalem, Israel