MedPath

Study of Sotorasib, Panitumumab and FOLFIRI Versus FOLFIRI With or Without Bevacizumab-awwb in Treatment-naïve Participants With Metastatic Colorectal Cancer With KRAS p.G12C Mutation

Phase 3
Recruiting
Conditions
Metastatic Colorectal Cancer
Interventions
Registration Number
NCT06252649
Lead Sponsor
Amgen
Brief Summary

The aim of this study is to compare progression free survival (PFS) in treatment-naïve Participants with KRAS p.G12C mutated metastatic colorectal cancer (mCRC) receiving sotorasib, panitumumab and FOLFIRI vs FOLFIRI with or without bevacizumab-awwb.

Detailed Description

Not available

Recruitment & Eligibility

Status
RECRUITING
Sex
All
Target Recruitment
450
Inclusion Criteria
  • Pathologically documented metastatic colorectal adenocarcinoma with KRAS p.G12C mutation by a locally validated assay.
  • Central confirmation of KRAS p.G12C mutation
  • Measurable metastatic disease per RECIST v1.1 criteria.
  • Eastern Cooperative Oncology Group (ECOG) Performance Status of ≤ 1.
  • Adequate organ function.
Exclusion Criteria
  • Active, untreated brain metastases.
  • Leptomeningeal disease
  • Previous treatment with a KRAS p.G12C inhibitor
  • History of interstitial pneumonitis or pulmonary fibrosis or evidence of interstitial pneumonitis or pulmonary fibrosis on baseline CT scan

Study & Design

Study Type
INTERVENTIONAL
Study Design
PARALLEL
Arm && Interventions
GroupInterventionDescription
Arm A: Sotorasib + Panitumumab + FOLFIRIFOLFIRI RegimenSotorasib was taken daily (QD) as an oral tablet. Panitumumab and FOLFIRI were received every 2 weeks (Q2W) via intravenous infusion (IV).
Arm B: FOLFIRI with or Without Bevacizumab-awwbFOLFIRI RegimenParticipants received FOLFIRI Q2W with or without bevacizumab-awwb.
Arm A: Sotorasib + Panitumumab + FOLFIRISotorasibSotorasib was taken daily (QD) as an oral tablet. Panitumumab and FOLFIRI were received every 2 weeks (Q2W) via intravenous infusion (IV).
Arm A: Sotorasib + Panitumumab + FOLFIRIPanitumumabSotorasib was taken daily (QD) as an oral tablet. Panitumumab and FOLFIRI were received every 2 weeks (Q2W) via intravenous infusion (IV).
Arm B: FOLFIRI with or Without Bevacizumab-awwbBevacizumab-awwbParticipants received FOLFIRI Q2W with or without bevacizumab-awwb.
Primary Outcome Measures
NameTimeMethod
PFS per Response Evaluation Criteria in Solid Tumors (RECIST v1.1)Up to Approximately 3 Years
Secondary Outcome Measures
NameTimeMethod
Overall Survival (OS)Up to Approximately 5 Years
Objective Response (OR) per RECIST v1.1Up to Approximately 3 Years
Duration of Response (DOR) per RECIST v1.1Up to Approximately 3 Years
Disease Control Rate (DCR) per RECIST v1.1up to Approximately 3 Years
Time to Response (TTR) per RECIST v1.1Up to approximately 3 Years
Depth of Response per RECIST v1.1Up to Approximately 3 Years

Depth of response is measured as the percentage of tumor shrinkage calculated as the best percentage change from baseline in lesion sum diameters.

Maximum Plasma Concentration (Cmax) of SotorasibDay 1 (pre-dose) to week 4 (post dose) on cycle 2 (one cycle = 28 days)
Time to Early Tumor Shrinkage (ETS) per RECIST v1.1Up to Approximately 3 Years
PFS Based on Investigator's Assessment per RECIST v1.1Up to Approximately 3 Years
Objective Response Rate (ORR) Based on Investigator's Assessment per RECIST v1.1Up to Approximately 3 years
DOR Based on Investigator's Assessment per RECIST v1.1up to Approximately 3 Years
DCR Based on Investigator's Assessment per RECIST v1.1Up to Approximately 3 Years
TTR Based on Investigator's Assessment per RECIST v1.1Up to Approximately 3 Years
Depth of Response Based on Investigator's Assessment per RECIST v1.1Up to Approximately 3 Years
Time to ETS Based on Investigator's Assessment per RECIST v1.1Up to Approximately 3 Years
Number of Participants Experiencing Adverse Events (AEs)Up to Approximately 3 Years

An AE is defined as any untoward medical occurrence in participant or clinical investigation subject administered a pharmaceutical product, which does not necessarily have to have a causal relationship with this treatment. A serious AE is defined as any AE that results in death, is life threatening, requires inpatient hospitalization or prolongation of existing hospitalization, results in persistent or significant disability/incapacity, is a congenital abnormality/birth defect or important medical events that do not meet the preceding criteria but based on appropriate medical judgment may jeopardize the patient or may require medical or surgical intervention to prevent any of the outcomes listed above.

Pre-dose (Ctrough) Concentrations of SotorasibDay 1 (pre-dose) to week 4 (post dose) on cycle 2 (one cycle = 28 days)

Trial Locations

Locations (227)

AZ Delta Campus Rumbeke

🇧🇪

Roeselare, Belgium

Hospital General Universitario Gregorio Maranon

🇪🇸

Madrid, Spain

Hospital Universitario 12 de Octubre

🇪🇸

Madrid, Spain

Ironwood Cancer and Research Centers Scottsdale

🇺🇸

Chandler, Arizona, United States

Providence Saint Jude Medical Center

🇺🇸

Fullerton, California, United States

Cancer and Blood Specialty Clinic

🇺🇸

Los Alamitos, California, United States

California Research Institute

🇺🇸

Los Angeles, California, United States

Norwalk Hospital

🇺🇸

Norwalk, Connecticut, United States

Cancer Specialists of North Florida

🇺🇸

Jacksonville, Florida, United States

D and H Cancer Research Center

🇺🇸

Margate, Florida, United States

Mid Florida Hematology and Oncology Centers PA

🇺🇸

Orange City, Florida, United States

Boca Raton Clinical Research Medical Center Inc

🇺🇸

Plantation, Florida, United States

Georgia Cancer Specialists

🇺🇸

Atlanta, Georgia, United States

Hope and Healing Cancer Services

🇺🇸

Hinsdale, Illinois, United States

Orchard Healthcare Research Inc

🇺🇸

Skokie, Illinois, United States

Pikeville Medical Center

🇺🇸

Pikeville, Kentucky, United States

Henry Ford Health System

🇺🇸

Detroit, Michigan, United States

Cancer and Hematology Centers of Western Michigan

🇺🇸

Grand Rapids, Michigan, United States

Saint Louis Cancer Care West County

🇺🇸

Bridgeton, Missouri, United States

Minniti Center for Medical Oncology and Hematology

🇺🇸

Mickleton, New Jersey, United States

Duke Cancer Center

🇺🇸

Durham, North Carolina, United States

FirstHealth Cancer Center

🇺🇸

Pinehurst, North Carolina, United States

Thomas Jefferson University

🇺🇸

Philadelphia, Pennsylvania, United States

Carolina Blood and Cancer Care

🇺🇸

Rock Hill, South Carolina, United States

Hospital Universitario Fundacion Favaloro

🇦🇷

Caba, Buenos Aires, Argentina

Instituto Argentino de Diagnóstico y Tratamiento

🇦🇷

Caba, Buenos Aires, Argentina

Investigaciones Clinicas Moleculares - Centro de Endocrinologia y Diabetes Dr Raul Gutman SRL

🇦🇷

Caba, Buenos Aires, Argentina

Cemic

🇦🇷

Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina

Sanatorio Británico de Rosario

🇦🇷

La Plata, Buenos Aires, Argentina

Instituto de Investigaciones clinicas de Mar del Plata

🇦🇷

Mar Del Plata, Buenos Aires, Argentina

Hospital Italiano de Córdoba

🇦🇷

Cordoba, Córdoba, Argentina

Sanatorio Allende

🇦🇷

Cordoba, Córdoba, Argentina

Clinica Universitaria Privada Reina Fabiola

🇦🇷

Cordoba, Córdoba, Argentina

Clinica Viedma

🇦🇷

Viedma, Río Negro, Argentina

Exelsus Oncologia Clinica

🇦🇷

San Miguel de Tucuman, Tucuman, Argentina

Hospital Britanico de Buenos Aires

🇦🇷

Buenos Aires, Argentina

Centro Oncologico Riojano Integral

🇦🇷

La Rioja, Argentina

Chris OBrien Lifehouse

🇦🇺

Camperdown, New South Wales, Australia

Toowoomba Hospital

🇦🇺

Toowoomba, Queensland, Australia

Flinders Medical Centre

🇦🇺

Bedford Park, South Australia, Australia

The Queen Elizabeth Hospital

🇦🇺

Woodville South, South Australia, Australia

Austin Health, Austin Hospital

🇦🇺

Heidelberg, Victoria, Australia

Ordensklinikum Linz Barmherzige Schwestern

🇦🇹

Linz, Austria

Landeskrankenhaus Feldkirch

🇦🇹

Rankweil, Austria

Universitaetsklinikum Allgemeines Krankenhaus Wien

🇦🇹

Wien, Austria

Institut Jules Bordet

🇧🇪

Brussels, Belgium

Universite Catholique de Louvain Cliniques Universitaires Saint Luc

🇧🇪

Bruxelles, Belgium

Grand Hôpital de Charleroi - Site des Viviers

🇧🇪

Charleroi, Belgium

Universitair Ziekenhuis Gent

🇧🇪

Gent, Belgium

Universitair Ziekenhuis Leuven - Campus Gasthuisberg

🇧🇪

Leuven, Belgium

Algemeen Ziekenhuis Sint-Maarten

🇧🇪

Mechelen, Belgium

Vitaz campus Sint-Niklaas Moerland

🇧🇪

Sint-Niklaas, Belgium

Hospital Sirio Libanes

🇧🇷

Brasilia, Distrito Federal, Brazil

Hospital Evangelico de Cachoeiro de Itapemirim

🇧🇷

Cachoeiro de Itapemirim, Espírito Santo, Brazil

Vencer e Oncoclinica

🇧🇷

Teresina, Piauí, Brazil

Liga Norte-Riograndense Contra O Cancer

🇧🇷

Natal, Rio Grande Do Norte, Brazil

Oncosite Centro de Pesquisa Clinica Em Oncologia Ltda

🇧🇷

Ijui, Rio Grande Do Sul, Brazil

Irmandade da Santa Casa de Misericordia de Porto Alegre

🇧🇷

Porto Alegre, Rio Grande Do Sul, Brazil

Associação Hospitalar Moinhos de Vento

🇧🇷

Porto Alegre, Rio Grande Do Sul, Brazil

Clinica de Neoplasias Litoral

🇧🇷

Itajai, Santa Catarina, Brazil

Fundacao Pio 12 Hospital de Amor de Barretos

🇧🇷

Barretos, São Paulo, Brazil

Oncoclinicas Belo Horizonte

🇧🇷

Barretos, São Paulo, Brazil

Fundacao Antonio Prudente AC Camargo Cancer Center

🇧🇷

Sao Paulo, São Paulo, Brazil

Oncologia Rede D Or

🇧🇷

Sao Paulo, São Paulo, Brazil

Hospital de Base de Sao Jose do Rio Preto

🇧🇷

São José do Rio Preto, São Paulo, Brazil

Oncoclinicas Rio de Janeiro S A

🇧🇷

Rio de Janeiro, Brazil

Instituto do Cancer do Estado de Sao Paulo Octavio Frias de Oliveira Icesp

🇧🇷

São Paulo, Brazil

Instituto Brasileiro de Controle do Cancer Ibcc

🇧🇷

São Paulo, Brazil

Specialized Hospital for Active Treatment of Oncology - Haskovo EOOD

🇧🇬

Haskovo, Bulgaria

Multiprofile Hospital for Active Treatment Central Onco Hospital OOD

🇧🇬

Plovdiv, Bulgaria

Complex Oncology Center Plovdiv EOOD

🇧🇬

Plovdiv, Bulgaria

Military Medical Academy Multiprofile Hospital for Active Treatment - Sofia

🇧🇬

Sofia, Bulgaria

Multiprofile Hospital for Active Treatment Serdika EOOD

🇧🇬

Sofia, Bulgaria

James Lind Centro de Investigacion del Cancer

🇨🇱

Temuco, Cautín, Chile

Centro de investigacion y desarrollo oncolgico Spa

🇨🇱

Temuco, Cautín, Chile

Clinica Redsalud Vitacura, Instituto del Cancer

🇨🇱

Vitacura, Santiago, Chile

Fundacion Arturo Lopez Perez

🇨🇱

Santiago, Chile

Centro de oncologia de precision Spa

🇨🇱

Santiago, Chile

Biocinetic

🇨🇱

Santiago, Chile

Clinical Research Chile SpA

🇨🇱

Valdivia, Chile

Institucion Prestadora de Servicios de Salud Sociedad Médica Rionegro SA Somer SA

🇨🇴

Rionegro, Antioquia, Colombia

Instituto Nacional de Cancerologia

🇨🇴

Bogota, Cundinamarca, Colombia

Centro de Tratamiento e Investigación sobre Cancer Luis Carlos Sarmiento Angulo Ctic

🇨🇴

Bogotá, Cundinamarca, Colombia

Instituto Medico de Alta Tecnologia sas - Imat sas

🇨🇴

Montería, Córdoba, Colombia

Fundacion Oftalmologica de Santander - Foscal

🇨🇴

Floridablanca, Santander, Colombia

Masarykuv onkologicky ustav

🇨🇿

Brno, Czechia

Fakultni nemocnice Olomouc

🇨🇿

Olomouc, Czechia

Fakultni nemocnice Kralovske Vinohrady

🇨🇿

Praha 10, Czechia

Fakultni nemocnice v Motole

🇨🇿

Praha 5, Czechia

Aalborg Sygehus

🇩🇰

Aalborg, Denmark

Aarhus University Hospital

🇩🇰

Aarhus N, Denmark

Rigshospitalet

🇩🇰

Copenhagen, Denmark

Odense University Hospital

🇩🇰

Odense C, Denmark

North Estonia Medical Centre Foundation

🇪🇪

Tallinn, Estonia

Centre Hospitalier Universitaire de Clermont Ferrand - Hopital Estaing

🇫🇷

Clermont-Ferrand cedex 1, France

Hopital Henri Mondor

🇫🇷

Creteil, France

Centre Hospitalier Universitaire de Dijon - Hopital du Bocage

🇫🇷

Dijon Cedex, France

Hopital Prive Jean Mermoz

🇫🇷

Lyon, France

Institut regional du Cancer Montpellier

🇫🇷

Montpellier Cedex 5, France

Centre Antoine Lacassagne

🇫🇷

Nice, France

Hopital Saint Louis

🇫🇷

Paris Cedex 10, France

Hopital Europeen Georges Pompidou

🇫🇷

Paris, France

Centre Hospitalier Universitaire de Bordeaux - Hopital Haut Leveque

🇫🇷

Pessac, France

Centre Hospitalier Universitaire de Poitiers

🇫🇷

Poitiers Cedex, France

Hopital Robert Debre

🇫🇷

Reims, France

Centre Hospitalier Universitaire de Rennes - Hopital Pontchaillou

🇫🇷

Rennes Cedex 9, France

Centre Hospitalier Universitaire Nord de Saint Etienne - Hopital Nord

🇫🇷

Saint Priest en Jarez, France

Institut de Cancerologie de l Ouest Rene Gauducheau

🇫🇷

Saint-Herblain Cedex, France

Institut de Cancerologie de Lorraine - Alexis Vautrin

🇫🇷

Vandoeuvre les Nancy Cedex, France

Charite - Universitaetsmedizin Berlin, Campus Virchow

🇩🇪

Berlin, Germany

Klinikum Chemnitz gGmbH

🇩🇪

Chemnitz, Germany

Universitaetsklinikum Dresden

🇩🇪

Dresden, Germany

Universitaetsklinikum Essen

🇩🇪

Essen, Germany

UCT Universitaeres Zentrum fuer Tumorerkrankungen Frankfurt

🇩🇪

Frankfurt am Main, Germany

Haematologisch Onkologische Praxis Eppendorf

🇩🇪

Hamburg, Germany

Regional Kliniken Holding Klinikum Ludwigsburg

🇩🇪

Ludwigsburg, Germany

Klinikum der LMU Muenchen

🇩🇪

Muenchen, Germany

Universitaetsklinikum Ulm

🇩🇪

Ulm, Germany

Klinikum der Stadt Wolfsburg

🇩🇪

Wolfsburg, Germany

General Hospital Evangelismos

🇬🇷

Athens, Greece

Agios Savvas Anticancer Hospital

🇬🇷

Athens, Greece

Metropolitan Hospital

🇬🇷

Athens, Greece

University Hospital of Larissa

🇬🇷

Larissa, Greece

Bioclinic of Thessaloniki

🇬🇷

Thessaloniki, Greece

Agios Loukas Clinic

🇬🇷

Thessaloniki, Greece

Saint Lukes Hospital SA

🇬🇷

Thessaloniki, Greece

European Interbalkan Medical Center

🇬🇷

Thessaloniki, Greece

Queen Mary Hospital, The University of Hong Kong

🇭🇰

Hong Kong, Hong Kong

Princess Margaret Hospital

🇭🇰

Kowloon, Hong Kong

Orszagos Onkologiai Intezet

🇭🇺

Budapest, Hungary

Debreceni Egyetem Klinikai Kozpont

🇭🇺

Debrecen, Hungary

Bekes Varmegyei Kozponti Korhaz Pandy Kalman Tagkorhaz

🇭🇺

Gyula, Hungary

Somogy Varmegyei Kaposi Mor Oktato Korhaz

🇭🇺

Kaposvar, Hungary

Szabolcs-Szatmar-Bereg Varmegyei Oktatokorhaz Nyiregyhazi Josa Andras Tagkorhaz

🇭🇺

Nyiregyhaza, Hungary

Jasz-Nagykun-Szolnok Varmegyei Hetenyi Geza Korhaz-Rendelointezet

🇭🇺

Szolnok, Hungary

Istituto Ospedaliero Fondazione Poliambulanza

🇮🇹

Brescia, Italy

Ente Ospedaliero IRCCS Saverio De Bellis

🇮🇹

Castellana Grotte, Italy

Azienda Ospedaliero Universitaria Careggi

🇮🇹

Firenze, Italy

Azienda Ospedaliero Universitaria Ospedali Riuniti di Foggia

🇮🇹

Foggia, Italy

Fondazione IRCCS Istituto Nazionale dei Tumori

🇮🇹

Milano, Italy

Azienda di Rilievo Nazionale e Alta Specializzazione Civico Di Cristina Benfratelli

🇮🇹

Palermo, Italy

Azienda Ospedaliero Universitaria Pisana

🇮🇹

Pisa, Italy

Azienda Sanitaria Universitaria Friuli Centrale Presidio Ospedaliero Santa Maria della Misericordia

🇮🇹

Udine, Italy

Azienda Ospedaliera Universitaria Integrata di Verona Ospedale Civile Maggiore Borgo Trento

🇮🇹

Verona, Italy

Aichi Cancer Center

🇯🇵

Nagoya-shi, Aichi, Japan

Chiba Cancer Center

🇯🇵

Chiba-shi, Chiba, Japan

National Cancer Center Hospital East

🇯🇵

Kashiwa-shi, Chiba, Japan

National Hospital Organization Shikoku Cancer Center

🇯🇵

Matsuyama-shi, Ehime, Japan

National Hospital Organization Kyushu Cancer Center

🇯🇵

Fukuoka-shi, Fukuoka, Japan

Hokkaido University Hospital

🇯🇵

Sapporo, Hokkaido, Japan

Hyogo Cancer Center

🇯🇵

Akashi-shi, Hyogo, Japan

St Marianna University Hospital

🇯🇵

Kawasaki-shi, Kanagawa, Japan

Yokohama City University Medical Center

🇯🇵

Yokohama-shi, Kanagawa, Japan

Kanagawa Prefectural Hospital Organization Kanagawa Cancer Center

🇯🇵

Yokohama-shi, Kanagawa, Japan

Niigata Cancer Center Hospital

🇯🇵

Niigata-shi, Niigata, Japan

Kansai Medical University Hospital

🇯🇵

Hirakata-shi, Osaka, Japan

National Hospital Organization Osaka National Hospital

🇯🇵

Osaka-shi, Osaka, Japan

The University of Osaka Hospital

🇯🇵

Suita-shi, Osaka, Japan

Saitama Cancer Center

🇯🇵

Kitaadachi-gun, Saitama, Japan

Shizuoka Cancer Center

🇯🇵

Sunto-gun, Shizuoka, Japan

Tokushima University Hospital

🇯🇵

Tokushima-shi, Tokushima, Japan

National Cancer Center Hospital

🇯🇵

Chuo-ku, Tokyo, Japan

The Cancer Institute Hospital of Japanese Foundation for Cancer Research

🇯🇵

Koto-ku, Tokyo, Japan

National Cancer Center

🇰🇷

Goyang-si Gyeonggi-do, Korea, Republic of

Korea University Anam Hospital

🇰🇷

Seoul, Korea, Republic of

Seoul National University Hospital

🇰🇷

Seoul, Korea, Republic of

Severance Hospital Yonsei University Health System

🇰🇷

Seoul, Korea, Republic of

Samsung Medical Center

🇰🇷

Seoul, Korea, Republic of

The Catholic University of Korea Seoul St Marys Hospital

🇰🇷

Seoul, Korea, Republic of

Instituto Portugues de Oncologia de Coimbra Francisco Gentil, EPE

🇵🇹

Coimbra, Portugal

Unidade Local de Saude de Coimbra, EPE

🇵🇹

Coimbra, Portugal

Korea University Guro Hospital

🇰🇷

Seoul, Korea, Republic of

Asan Medical Center

🇰🇷

Seoul, Korea, Republic of

Centro Especializado en Investigacion y Tratamiento Oncologicos SC

🇲🇽

Benito Juárez, Distrito Federal, Mexico

Health Pharma Professional Research SA de CV

🇲🇽

Mexico City, Distrito Federal, Mexico

Hospital Universitario Dr Jose Eleuterio Gonzalez

🇲🇽

Monterrey, Nuevo León, Mexico

Nederlands Kanker Instituut - Antoni van Leeuwenhoek

🇳🇱

Amsterdam, Netherlands

Medisch Spectrum Twente

🇳🇱

Enschede, Netherlands

Unidade de Saude Local de Almada-Seixal, EPE - Hospital Garcia de Orta

🇵🇹

Almada, Portugal

Hospital Cuf Tejo

🇵🇹

Lisboa, Portugal

Fundacao Champalimaud

🇵🇹

Lisboa, Portugal

Hospital da Luz, SA

🇵🇹

Lisboa, Portugal

Unidade Local de Saude de Santa Maria, EPE - Hospital de Santa Maria

🇵🇹

Lisboa, Portugal

Unidade Local de Saude de Matosinhos, EPE - Hospital Pedro Hispano

🇵🇹

Matosinhos, Portugal

Unidade Local de Saude de Entre Douro e Vouga, EPE - Hospital de Sao Sebastiao

🇵🇹

Santa Maria da Feira, Portugal

Institutul Clinic Fundeni

🇷🇴

Bucharest, Romania

Institutul Oncologic Prof Dr Alexandru Trestioreanu Bucuresti

🇷🇴

Bucuresti, Romania

Institutul Oncologic Prof Dr Ion Chiricuta Cluj-Napoca

🇷🇴

Cluj Napoca, Romania

Centrul de Oncologie Sf Nectarie SRL

🇷🇴

Craiova, Romania

Institutul Regional de Oncologie Iasi

🇷🇴

Iasi, Romania

Spitalul Municipal Ploiesti

🇷🇴

Ploiesti, Romania

SC Oncomed SRL

🇷🇴

Timisoara, Romania

Hospital Universitario Reina Sofia

🇪🇸

Cordoba, Andalucía, Spain

Hospital Universitario Virgen de las Nieves

🇪🇸

Granada, Andalucía, Spain

Hospital Regional Universitario de Malaga

🇪🇸

Malaga, Andalucía, Spain

Hospital Universitario Virgen del Rocio

🇪🇸

Sevilla, Andalucía, Spain

Hospital Universitario Central de Asturias

🇪🇸

Oviedo, Asturias, Spain

Hospital Universitario Marques de Valdecilla

🇪🇸

Santander, Cantabria, Spain

Hospital Universitario de Burgos

🇪🇸

Burgos, Castilla León, Spain

Hospital Universitari Vall d Hebron

🇪🇸

Barcelona, Cataluña, Spain

Hospital de la Santa Creu i Sant Pau

🇪🇸

Barcelona, Cataluña, Spain

Hospital General Universitario de Elche

🇪🇸

Elche, Comunidad Valenciana, Spain

Hospital Clinico Universitario de Valencia

🇪🇸

Valencia, Comunidad Valenciana, Spain

Hospital General Universitario de Valencia

🇪🇸

Valencia, Comunidad Valenciana, Spain

Complexo Hospitalario Universitario de Ourense

🇪🇸

Ourense, Galicia, Spain

Hospital Universitario de Navarra

🇪🇸

Pamplona, Navarra, Spain

Hospital Universitario La Paz

🇪🇸

Madrid, Spain

Södersjukhuset, onkologikliniken

🇸🇪

Stockholm, Sweden

Universitaetsspital Zuerich

🇨🇭

Zuerich, Switzerland

China Medical University Hospital

🇨🇳

Taichung, Taiwan

Taichung Veterans General Hospital

🇨🇳

Taichung, Taiwan

Taipei Veterans General Hospital

🇨🇳

Taipei, Taiwan

Linkou Chang Gung Memorial Hospital of Chang Gung Medical Foundation

🇨🇳

Taoyuan, Taiwan

Siriraj Hospital

🇹🇭

Bangkok, Thailand

Adana Sehir Egitim ve Arastirma Hastanesi

🇹🇷

Adana, Turkey

Hacettepe Universitesi Tip Fakultesi Hastanesi

🇹🇷

Ankara, Turkey

Gazi Universitesi Saglik Arastirma ve Uygulama Merkezi Gazi Hastanesi

🇹🇷

Ankara, Turkey

Ankara Universitesi Tip Fakultesi Hastanesi

🇹🇷

Ankara, Turkey

Ankara Bilkent Sehir Hastanesi

🇹🇷

Ankara, Turkey

Trakya Universitesi Saglik Arastirma ve Uygulama Merkezi

🇹🇷

Edirne, Turkey

Bezmialem Vakif Universitesi Hastanesi

🇹🇷

Istanbul, Turkey

Bagcilar Medipol Mega Universite Hastanesi

🇹🇷

Istanbul, Turkey

Acibadem Altunizade Hastanesi

🇹🇷

Istanbul, Turkey

Ege Universitesi Tip Fakultesi Hastanesi

🇹🇷

Izmir, Turkey

Necmettin Erbakan Universitesi Tip Fakultesi Hastanesi

🇹🇷

Konya, Turkey

Inonu Universitesi Turgut Ozal Tip Merkezi

🇹🇷

Malatya, Turkey

Sarah Cannon Research Institute UK

🇬🇧

London, United Kingdom

© Copyright 2025. All Rights Reserved by MedPath