NCT01231295已完成不适用
Evaluating the Performance of Isotopic Brain Imaging of Glucose Metabolism Via PET (18F-FDG) and Perfusion SPECT (99mTc-ECD) for the Diagnosis of Prodromal Stage Alzheimer's Disease
Centre Hospitalier Universitaire de Nīmes25 个研究点 分布在 1 个国家目标入组 143 人开始时间: 2011年2月最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 143
- 试验地点
- 25
- 主要终点
- The difference between AUCs for PET and SPECT imaging
研究概览
简要总结
The primary objective of this study is to characterize cerebral metabolism modifications using 18F-FDG PET technology and perfusion with 99MTC-ECD SPECT in patients with prodromal Alzheimer's Disease drawn from a high risk population. We also compare PET and SPECT imaging within this framework, and search for optimal diagnostic thresholds.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 70 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- •Instrumental Activities of Daily Living (IADL): at least two items > 1
- •Anticholinesterasic treatments and/or memantin before study inclusion
- •major depressive syndrome, according to the Global Depressive Scale
- •Known neurodegenerative disease or general disease or major physical problems that could interfere with cognitive functioning and testing
- •Pathology that might lead to death in the short term (evolving cancer, non stable cardiopathy, hepatic, renal or respiratory insufficiency)
- •contra-indications for MRI, PET or SPECT scans
- •not affiliated with a social security regimen
结局指标
主要结局
The difference between AUCs for PET and SPECT imaging
时间窗: 1 month
The difference between the AUCs (area under the curve) for PET and SPECT imaging.
次要结局
未报告次要终点
研究者
研究点 (25)
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