IRCT20170809035597N2
Completed
Phase 3
Evaluation of the efficacy and safety of oral pentoxifylline in treatment and recovery of patients with COVID-19 admitted in Rasoul Akram and firoozgar hospitals treated with routine protocols, A randomized controlled clinical trial
Overview
- Phase
- Phase 3
- Intervention
- Not specified
- Conditions
- Not specified
- Sponsor
- Iran University of Medical Sciences
- Enrollment
- 150
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Admitted patients with COVID\-19
- •Moderate to severe disease
- •Stable patients
- •Patients should not have bleeding disorders
- •Patients do not have a history of heart attack and stroke
- •Patients without history of ocular or cerebral hemorrhage
- •No pregnancy or breastfeeding
- •Patients without history of intolerance to PTX or other xanthines such as caffeine, theophylline and tobromine
- •Patients without gastric ulcers
- •Patient without history of porphyria
Exclusion Criteria
- •Allergy to any of the drugs studied, including pentoxifylline
- •Occurrence of any bleeding during the study (in the stomach, brain, eyes, ...)
- •Drug intolerance or the occurrence of any severe side effects during treatment, such as gastrointestinal intolerance, does not respond to pre\-determined measures of anti\-acids... or the occurrence of skin drug reactions to the received treatment protocol and ...
- •Being pregnant during the study
- •Occurrence of heart attack and stroke during the study
- •Drop in pressure below 10 mm Hg or instability of the patient's vital signs
- •Require intubation during study or hospitalization in the ICU
- •Increase in the severity of COVID\-19 disease during the study so that the need for hospitalization in the ICU or the need to change the treatment protocol
- •The use of a therapeutic drug other than the standard drug in this study
Outcomes
Primary Outcomes
Not specified
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