ISRCTN92186858已完成未知
Can high-dose vitamin D supplementation reduce blood pressure and markers of cardiovascular risk in older people with isolated systolic hypertension? A randomised, double-blind, parallel group placebo controlled trial
niversity of Dundee (UK)0 个研究点目标入组 180 人开始时间: 2008年8月21日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 180
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •1. Aged greater than or equal to 70 years, either sex
- •2. Office systolic blood pressure (BP) greater than 140 mmHg
- •3. Serum 25 hydroxy vitamin D less than 75 nmol/
排除标准
- •1. Hypertension known to be due to a correctable underlying medical or surgical cause
- •2. Diastolic blood pressure greater than 90 mmHg
- •3. Systolic blood pressure greater than 180 mmHg
- •4. Estimated glomerular filtration rate less than 40 ml/min (by four-variable modification of diet in renal disease rate [MDRD] equation)
- •5. Liver function tests (alanine aminotransferase [ALT], bilirubin, alkaline phosphatase) greater than 3 x normal
- •6. Corrected calcium greater than 2.60 mmol/L or less than 2.15 mmol/L
- •7. Known metastatic malignancy or sarcoidosis
- •8. Clinical diagnosis of osteomalacia
- •9. History of renal calculi
- •10. Diagnosis of heart failure with left ventricular systolic dysfunction
- •11. Atrial fibrillation
- •12. Already taking vitamin D supplements (consumption of fish oils will not be a contraindication to enrolment)
- •13. Unable to give written informed consent
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